Manager, CMO Operations, VMT Lead (Autologous CAR-T)
Legend Biotech
June 28, 2026
Remote friendly (Raritan, NJ)
United States
Operations
Role Overview
Manager, CMO Operations - VMT Lead (Autologous CAR T)
Key Responsibilities
- Own end-to-end operational execution at CMOs from apheresis through final drug product release and shipment.
- Ensure flawless, compliant execution of commercial manufacturing plans aligned to patient schedules and demand forecasts.
- Track and manage batch status, deviations, and execution risks across the full manufacturing lifecycle.
- Track/compile/review/report KPI performance metrics.
- Serve as VMT Lead for assigned CMOs; drive performance management using agreed KPIs and governance.
- Lead routine business reviews, performance deep dives, and escalation forums with CMOs and internal stakeholders.
- Proactively identify operational, capacity, and compliance risks; maintain risk registers and mitigation plans.
- Lead cross-functional problem-solving for deviations, supply interruptions, and systemic issues; ensure contingency planning.
- Drive continuous improvement (reliability, cycle time, yield, right-first-time); support capacity expansions, technology transfers, and process improvement.
- Build relationships with Quality, MSAT, Planning, Supply Chain, and Clinical/Commercial Operations; communicate status, risks, and mitigations.
Requirements
- Bachelor’s degree+ in engineering, biological sciences, pharmaceutical sciences, or related field.
- 5+ years in biologics CMC development or commercial manufacturing; cell therapy and/or autologous CAR-T experience preferred.
- Hands-on experience managing CMOs and/or CROs in regulated manufacturing.
- Strong GMP operations, deviation management, and supply risk management.
- Strong analytical/problem-solving skills; excellent communication and stakeholder management.
- Ability to lead through influence in a matrixed, cross-functional organization.
Benefits (if applicable)
- Medical, dental, vision; 401(k) match; 8 weeks paid parental leave after 3 months; paid time off and 11 company holidays.
Manager, CMO Operations - VMT Lead (Autologous CAR T)
Key Responsibilities
- Own end-to-end operational execution at CMOs from apheresis through final drug product release and shipment.
- Ensure flawless, compliant execution of commercial manufacturing plans aligned to patient schedules and demand forecasts.
- Track and manage batch status, deviations, and execution risks across the full manufacturing lifecycle.
- Track/compile/review/report KPI performance metrics.
- Serve as VMT Lead for assigned CMOs; drive performance management using agreed KPIs and governance.
- Lead routine business reviews, performance deep dives, and escalation forums with CMOs and internal stakeholders.
- Proactively identify operational, capacity, and compliance risks; maintain risk registers and mitigation plans.
- Lead cross-functional problem-solving for deviations, supply interruptions, and systemic issues; ensure contingency planning.
- Drive continuous improvement (reliability, cycle time, yield, right-first-time); support capacity expansions, technology transfers, and process improvement.
- Build relationships with Quality, MSAT, Planning, Supply Chain, and Clinical/Commercial Operations; communicate status, risks, and mitigations.
Requirements
- Bachelor’s degree+ in engineering, biological sciences, pharmaceutical sciences, or related field.
- 5+ years in biologics CMC development or commercial manufacturing; cell therapy and/or autologous CAR-T experience preferred.
- Hands-on experience managing CMOs and/or CROs in regulated manufacturing.
- Strong GMP operations, deviation management, and supply risk management.
- Strong analytical/problem-solving skills; excellent communication and stakeholder management.
- Ability to lead through influence in a matrixed, cross-functional organization.
Benefits (if applicable)
- Medical, dental, vision; 401(k) match; 8 weeks paid parental leave after 3 months; paid time off and 11 company holidays.