Director/Senior Director, HEOR Modeling and Evidence Synthesis

Role: Senior or Director-level HEOR Modeling & Evidence Synthesis expert leading health economic modeling and systematic literature reviews to support Axsome’s CNS product portfolio. Responsibilities: develop, validate, and communicate complex decision-analytic models—including cost-effectiveness, budget impact, and disease progression models—for marketed and pipeline assets across rare and prevalent CNS conditions; lead systematic reviews, indirect treatment comparisons, and network meta-analyses; advise cross-functional stakeholders on evidence strategies and communicate findings to technical and non-technical audiences; establish modeling standards and mentor colleagues. Requirements: PhD/MD/DrPH or similar in health economics, epidemiology, biostatistics, or related field; 10+ years supporting biopharmaceuticals with extensive experience in health economic modeling, evidence synthesis, and systematic reviews; demonstrated leadership in complex modeling projects; proficiency in Excel, R, and other simulation tools; deep knowledge of clinical, epidemiologic, and economic inputs; experience with ICER assessments, payer evidence requirements, and lifecycle management. HighValue: CNS indications, including major depressive disorder, dementia-related agitation, narcolepsy, migraine; experience with rare/prevalent conditions, long-term care, and US reimbursement landscape; hands-on expertise with systematic reviews, network meta-analyses, and modeling validation; on-site in New York City (3 days/week), no remote option. Collaborates with HEOR, Medical Strategy, Market Access, and publications teams.