Director, Project Management

Role Summary

Madrigal Pharmaceuticals is seeking a results-oriented Director of Project Management to oversee the planning, resourcing, and execution of R&D programs and cross-functional initiatives. Covering the full product lifecycle – from early development to post-marketing requirements – the Director will partner closely with clinical and functional leaders to build and maintain integrated project plans and ensure delivery on time and within scope. Reporting to the Vice President of Project and Portfolio Management (PPM), this role will be instrumental in driving operational excellence, advancing key milestones, and supporting the success of Madrigal’s development programs.

Responsibilities

• Drive Project Planning: Lead development and maintenance of detailed integrated project plans for multiple R&D programs, studies, and/or projects, ensuring alignment with overall Corporate objectives
• Ensure Project Delivery: Manage project timelines, deliverables, and budgets, proactively identifying and resolving risks or delays, escalating when appropriate
• Influence Optimal Resourcing: Partner with functional leaders to anticipate resource needs, resolve gaps, and ensure effective allocation of talent and capabilities within project scope
• Coordinate Functional Contributions: Partner closely with clinical, regulatory, CMC, and other functional leads to ensure their workstreams are aligned
• Enable Strategic Decision-Making: Provide insights and scenario analyses that inform trade-offs, prioritization, investment decisions within project teams
• Facilitate Team Operations: Serve as the central operational lead for assigned project teams – setting agendas, tracking actions, and ensuring effective communication yielding results
• Implement Best Practices: Promote project management standards, tools, dashboards, and processes that drive efficiency and continuous improvement within project teams
• Support Portfolio Review and Governance: Contribute operational support and content to project and portfolio reviews, governance bodies, and other forums as required
• Mentor and Guide Teams: Serve as a trusted thought partner to project teams, providing hands-on coaching, structure, and accountability within the project management disciple
• Support R&D Initiatives: Partner with VP, PPM on cross-department initiatives, contributing project management and operational support as needed

Specialized Knowledge & Skills

• Demonstrated success in managing complex, cross-functional drug development program teams
• Understanding of drug development process from discovery through commercialization
• Proficiency with project management software (e.g., SmartSheet, MS Project, etc.)
• Strong ability to synthesize, distill, and succinctly communicate strategy, plan, and status for multiple complex, cross-functional programs to all audiences
• Experience in operating model, governance, and process design and implementation within R&D environments
• Excellent organizational and interpersonal skills, with a track record of leading and influencing cross-functional teams
• Outstanding written and verbal communication skills
• Self-motivated and able to multi-task within a fast-paced environment
• Comfortable with and skilled at navigating ambiguity
• Ability to lead and influence without authority
• Experience working in both small biotech and larger pharmaceutical company environments preferred
• Experience in metabolic or rare disease therapeutic areas preferred

Requirements

• Bachelor’s degree in scientific or relevant business discipline required. Applicable advanced degree (e.g., MA, MBA, PhD, MD) a plus.
• 3 days per week in office in Conshohocken, PA

Experience

• 12+ years of relevant experience including a minimum 10 years project management experience