Director, Clinical Research
Alnylam Pharmaceuticals
September 02, 2026
Remote friendly (Cambridge, MA)
United States
Clinical Research and Development
Key Responsibilities
- Be the strategic leader providing a strong, clear voice for the clinical program.
- Develop creative but realistic approaches to drug development and lead clinical efforts to secure global regulatory approvals.
- Provide oversight of trial conduct and safety.
- Provide strategic consultation and guidance to Research on decisions with significant clinical components and implications.
- Collaborate closely with Preclinical, Regulatory Affairs, and Medical Affairs to ensure tight strategic integration of product development plans.
- Be accountable for relevant timelines and deliverables via Clinical Research and Operations.
- Supervise major written deliverables (regulatory submissions, original articles, abstracts) and presentation materials.
- Perform final review and sign-off for controlled documents (protocols, investigator brochures, informed consent forms).
- Influence internal and external audiences in a high-impact, highly visible manner.
Qualifications
- MD with a strong research background or MD PhD with top-tier clinical and/or research training supported by research support and peer-reviewed publications.
- Board Certification (or equivalent) or specialist training in cardiology.
- Expertise in heart failure and/or amyloidosis (desirable).
- 3+ years industry experience or equivalent clinical academic experience.
- Sound scientific and clinical judgment.
- Familiarity with clinical research and clinical trial design (including biostatistics) and regulatory agency organization, guidelines, and practices.
- Ability to effectively present and document complex medical/clinical concepts in written and oral communication.
- Track record of problem-solving with superior judgment and balanced, realistic issue assessment.
- Outstanding leadership and collaboration skills in a matrix environment.
- Experience/knowledge working with biotech/pharma partners.
- Thrives in an entrepreneurial biotech environment.
Hybrid/Location
- Hybrid: 2 days/week onsite in Cambridge, MA or Philadelphia, PA.
U.S. Pay Range
- $255,000.00 - $345,000.00 (eligible for annual short-term incentive and annual long-term incentive).
Benefits
- Medical, dental, and vision; life and disability insurance; lifestyle reimbursement; flexible spending and health savings accounts; 401(k) with company match; paid time off, wellness days, holidays, and recharge breaks.
Application Instructions
- Learn more about benefits at https://www.alnylam.com/careers
- Be the strategic leader providing a strong, clear voice for the clinical program.
- Develop creative but realistic approaches to drug development and lead clinical efforts to secure global regulatory approvals.
- Provide oversight of trial conduct and safety.
- Provide strategic consultation and guidance to Research on decisions with significant clinical components and implications.
- Collaborate closely with Preclinical, Regulatory Affairs, and Medical Affairs to ensure tight strategic integration of product development plans.
- Be accountable for relevant timelines and deliverables via Clinical Research and Operations.
- Supervise major written deliverables (regulatory submissions, original articles, abstracts) and presentation materials.
- Perform final review and sign-off for controlled documents (protocols, investigator brochures, informed consent forms).
- Influence internal and external audiences in a high-impact, highly visible manner.
Qualifications
- MD with a strong research background or MD PhD with top-tier clinical and/or research training supported by research support and peer-reviewed publications.
- Board Certification (or equivalent) or specialist training in cardiology.
- Expertise in heart failure and/or amyloidosis (desirable).
- 3+ years industry experience or equivalent clinical academic experience.
- Sound scientific and clinical judgment.
- Familiarity with clinical research and clinical trial design (including biostatistics) and regulatory agency organization, guidelines, and practices.
- Ability to effectively present and document complex medical/clinical concepts in written and oral communication.
- Track record of problem-solving with superior judgment and balanced, realistic issue assessment.
- Outstanding leadership and collaboration skills in a matrix environment.
- Experience/knowledge working with biotech/pharma partners.
- Thrives in an entrepreneurial biotech environment.
Hybrid/Location
- Hybrid: 2 days/week onsite in Cambridge, MA or Philadelphia, PA.
U.S. Pay Range
- $255,000.00 - $345,000.00 (eligible for annual short-term incentive and annual long-term incentive).
Benefits
- Medical, dental, and vision; life and disability insurance; lifestyle reimbursement; flexible spending and health savings accounts; 401(k) with company match; paid time off, wellness days, holidays, and recharge breaks.
Application Instructions
- Learn more about benefits at https://www.alnylam.com/careers