Director - Application Site-Reliability Engineering
Caris Life Sciences
August 26, 2026
Remote friendly (Irving, TX)
United States
IT
Job Responsibilities:
- Own the production-support model for the clinical application portfolio (on-call rotation, escalation procedures, incident-response playbooks).
- Establish/audit production-access and segregation-of-duties controls; maintain SOX ITGC and applicable FDA audit-ready evidence (access grants, role changes, privileged-action logs).
- Define and manage clinical SLOs, error budgets, and availability targets; track MTTD/MTTR and on-call burden; intervene before error budgets are spent.
- Lead incident response for high-severity events as incident commander/senior technical responder; coordinate teams, run post-incident reviews, drive remediation to closure.
- Develop runbooks and approved operational automation; enable safe, documented standard interventions.
- Drive automation-first operations (reduce toil; favor self-service tooling over ticket requests).
- Coordinate deployments, verify health, and own rollback decisions.
- Produce audit-ready change/deployment evidence via CI/CD pipelines.
- Hire/develop the App-SRE team; set expectations and career growth frameworks.
- Own application-layer observability (dashboards, alerts, SLO monitors) and represent App-SRE in leadership/compliance forums.
- Run the function AI-first (AI-assisted runbooks, incident analysis, operational tooling).
Required Qualifications:
- BS in CS/SE/IS (or equivalent) + 10+ years SRE/DevOps/platform/production ops.
- 4+ years people-management/team-lead experience.
- Hands-on incident response leadership for Tier 1/business-critical systems.
- Experience defining/implementing SLOs/error budgets and on-call workflows.
- Experience building/maturing production support/on-call/SRE (runbooks, rotation design).
- Experience operating under regulated/financial-controls frameworks (e.g., SOX ITGCs, HIPAA, FDA/CAP/CLIA) with audit-capable documentation.
- Track record applying AI-assisted practice to operations/engineering.
Preferred Qualifications:
- Clinical diagnostics/lab/molecular pathology/digital health domain experience.
- Direct SOX ITGC audit or CAP/CLIA inspection support with evidence gathering.
- Cloud-native observability knowledge (telemetry/tracing/APM).
- Deployment/release/rollback experience in continuous delivery.
- Player-coach ability; automation-toil reduction track record; experience presenting strategy/risk to executives.
- Own the production-support model for the clinical application portfolio (on-call rotation, escalation procedures, incident-response playbooks).
- Establish/audit production-access and segregation-of-duties controls; maintain SOX ITGC and applicable FDA audit-ready evidence (access grants, role changes, privileged-action logs).
- Define and manage clinical SLOs, error budgets, and availability targets; track MTTD/MTTR and on-call burden; intervene before error budgets are spent.
- Lead incident response for high-severity events as incident commander/senior technical responder; coordinate teams, run post-incident reviews, drive remediation to closure.
- Develop runbooks and approved operational automation; enable safe, documented standard interventions.
- Drive automation-first operations (reduce toil; favor self-service tooling over ticket requests).
- Coordinate deployments, verify health, and own rollback decisions.
- Produce audit-ready change/deployment evidence via CI/CD pipelines.
- Hire/develop the App-SRE team; set expectations and career growth frameworks.
- Own application-layer observability (dashboards, alerts, SLO monitors) and represent App-SRE in leadership/compliance forums.
- Run the function AI-first (AI-assisted runbooks, incident analysis, operational tooling).
Required Qualifications:
- BS in CS/SE/IS (or equivalent) + 10+ years SRE/DevOps/platform/production ops.
- 4+ years people-management/team-lead experience.
- Hands-on incident response leadership for Tier 1/business-critical systems.
- Experience defining/implementing SLOs/error budgets and on-call workflows.
- Experience building/maturing production support/on-call/SRE (runbooks, rotation design).
- Experience operating under regulated/financial-controls frameworks (e.g., SOX ITGCs, HIPAA, FDA/CAP/CLIA) with audit-capable documentation.
- Track record applying AI-assisted practice to operations/engineering.
Preferred Qualifications:
- Clinical diagnostics/lab/molecular pathology/digital health domain experience.
- Direct SOX ITGC audit or CAP/CLIA inspection support with evidence gathering.
- Cloud-native observability knowledge (telemetry/tracing/APM).
- Deployment/release/rollback experience in continuous delivery.
- Player-coach ability; automation-toil reduction track record; experience presenting strategy/risk to executives.