Computational Chemistry Senior Research Scientist
Vertex Pharmaceuticals
8 hours ago
Remote friendly (San Diego, CA)
United States
Other
Senior Research Scientist in Computational Drug Design (San Diego, CA)
Responsibilities
- Lead computational chemistry efforts for active drug discovery programs; translate computational insights into actionable design hypotheses with medicinal chemists, structural biologists, and DMPK.
- Develop and apply state-of-the-art computational chemistry methods, including ML, free energy perturbation (FEP), QSAR, and molecular modeling.
- Design and implement innovative in-silico strategies to address key drug discovery challenges.
- Partner with Computational Drug Design and Chemical Data Science teams to integrate novel methodologies.
- Drive cross-department communication to integrate computational workflows into discovery pipelines.
- Improve computational tools and methodologies with the global Data and Computational Sciences (DCS) group.
Qualifications / Skills
- Hands-on experience with virtual screening, programming, statistics, data analysis, and ADME modeling.
- Expertise in structure-based and/or ligand-based drug discovery molecular modeling.
- Deep knowledge of computational chemistry (FEP, ML, QSAR).
- Proficiency with commercial and open-source molecular modeling/data mining software.
- Strong analytical/problem-solving skills; excellent written/verbal communication.
Education / Experience
- Ph.D. (engineering/science/math) + 2–5 years post-doc; or Master’s + 5+ years; or Bachelor’s + 8+ years; track record of innovative computational tools/methodologies.
Compensation / Benefits
- Pay range: $125,600–$188,400; eligible for annual bonus and annual equity awards.
- Total rewards include medical/dental/vision, paid time off, educational assistance, commuting subsidy, matching donations, 401(k), etc.
Flex
- Hybrid (remote up to 2 days/week) or On-Site (5 days/week).
Application instructions
- For hiring-process accommodation: ApplicationAssistance@vrtx.com.
Responsibilities
- Lead computational chemistry efforts for active drug discovery programs; translate computational insights into actionable design hypotheses with medicinal chemists, structural biologists, and DMPK.
- Develop and apply state-of-the-art computational chemistry methods, including ML, free energy perturbation (FEP), QSAR, and molecular modeling.
- Design and implement innovative in-silico strategies to address key drug discovery challenges.
- Partner with Computational Drug Design and Chemical Data Science teams to integrate novel methodologies.
- Drive cross-department communication to integrate computational workflows into discovery pipelines.
- Improve computational tools and methodologies with the global Data and Computational Sciences (DCS) group.
Qualifications / Skills
- Hands-on experience with virtual screening, programming, statistics, data analysis, and ADME modeling.
- Expertise in structure-based and/or ligand-based drug discovery molecular modeling.
- Deep knowledge of computational chemistry (FEP, ML, QSAR).
- Proficiency with commercial and open-source molecular modeling/data mining software.
- Strong analytical/problem-solving skills; excellent written/verbal communication.
Education / Experience
- Ph.D. (engineering/science/math) + 2–5 years post-doc; or Master’s + 5+ years; or Bachelor’s + 8+ years; track record of innovative computational tools/methodologies.
Compensation / Benefits
- Pay range: $125,600–$188,400; eligible for annual bonus and annual equity awards.
- Total rewards include medical/dental/vision, paid time off, educational assistance, commuting subsidy, matching donations, 401(k), etc.
Flex
- Hybrid (remote up to 2 days/week) or On-Site (5 days/week).
Application instructions
- For hiring-process accommodation: ApplicationAssistance@vrtx.com.