Associate Scientist, Synthesis Process Development
Bristol Myers Squibb
June 26, 2026
On-site
Cambridge, MA
Operations
Responsibilities:
- Execute hands-on RNA synthesis process development and scale-up experiments (bench to pilot scale)
- Design/perform DoE-based in vitro transcription reaction optimization and characterization (e.g., QbD)
- Support downstream purification unit operations (chromatography, UF/DF) and process optimization bridging synthesis and purification
- Author/review technical protocols, experimental reports, and batch records for early- to late-stage development
- Perform analytical testing to assess RNA purity, concentration, and key quality attributes
- Analyze/interpret results and present findings to senior scientists and project teams
- Collaborate with internal R&D, analytical development, and manufacturing; support interactions with manufacturing partners and technology transfer
- Maintain accurate laboratory notebooks and documentation per internal quality standards
Qualifications:
- BS with 1+ years industry experience, or MS with relevant experience in Chemical Engineering, Biomedical Engineering, Biochemistry, or related
- Hands-on RNA synthesis experience, specifically in vitro transcription
- Familiarity with RNA quality analytical tools (gel electrophoresis, HPLC, capillary electrophoresis)
- Basic understanding of RNA purification unit operations
- Strong lab fundamentals; comfortable with bench-top equipment (e.g., bioreactors, FPLCs, UF/DF skids)
- Ability to organize/analyze experimental data, identify trends, and communicate results
- Exposure to GMP/cGMP is a plus (not required)
- DoE and/or statistical analysis software experience is a plus
Benefits (highlights): Medical, pharmacy, dental, vision; wellbeing programs (e.g., EAP); 401(k), disability, life insurance, and more; Paid Time Off (flexible time off or vacation/holidays depending on location).
Compensation: Cambridge, MA: $96,010–$116,339.
Application instructions: If the role isn’t a perfect match, apply anyway.
- Execute hands-on RNA synthesis process development and scale-up experiments (bench to pilot scale)
- Design/perform DoE-based in vitro transcription reaction optimization and characterization (e.g., QbD)
- Support downstream purification unit operations (chromatography, UF/DF) and process optimization bridging synthesis and purification
- Author/review technical protocols, experimental reports, and batch records for early- to late-stage development
- Perform analytical testing to assess RNA purity, concentration, and key quality attributes
- Analyze/interpret results and present findings to senior scientists and project teams
- Collaborate with internal R&D, analytical development, and manufacturing; support interactions with manufacturing partners and technology transfer
- Maintain accurate laboratory notebooks and documentation per internal quality standards
Qualifications:
- BS with 1+ years industry experience, or MS with relevant experience in Chemical Engineering, Biomedical Engineering, Biochemistry, or related
- Hands-on RNA synthesis experience, specifically in vitro transcription
- Familiarity with RNA quality analytical tools (gel electrophoresis, HPLC, capillary electrophoresis)
- Basic understanding of RNA purification unit operations
- Strong lab fundamentals; comfortable with bench-top equipment (e.g., bioreactors, FPLCs, UF/DF skids)
- Ability to organize/analyze experimental data, identify trends, and communicate results
- Exposure to GMP/cGMP is a plus (not required)
- DoE and/or statistical analysis software experience is a plus
Benefits (highlights): Medical, pharmacy, dental, vision; wellbeing programs (e.g., EAP); 401(k), disability, life insurance, and more; Paid Time Off (flexible time off or vacation/holidays depending on location).
Compensation: Cambridge, MA: $96,010–$116,339.
Application instructions: If the role isn’t a perfect match, apply anyway.