Associate Scientist/Sr. Associate Scientist/Scientist, Islet Process Sciences
Century Therapeutics, Inc
June 25, 2026
On-site
Watertown, MA
Operations
Role (Process Science – CNTY-813 beta islet cell therapy):
- Execute iPSC maintenance, scale-up preparation, 3D aggregate culture, and directed differentiation toward pancreatic islet-like cell populations.
- Design, run, and troubleshoot suspension-based differentiation experiments in scalable formats (including PBS Vertical Wheel bioreactors when appropriate).
- Operate controlled bioreactor systems and monitor inputs (pH, dissolved oxygen, agitation, inoculation density, feeding strategy, media exchange, culture timing).
- Innovate across workflow: signaling timing; growth factor/cytokine conditions; media/feed strategies; aggregate handling; cryopreservation/recovery; and culture-format changes to improve cell fate, scalability, and performance.
- Develop and optimize process parameters to improve endocrine commitment, beta cell identity, reproducibility, recovery, cryopreservation compatibility, and scalability.
- Apply Quality by Design and DOE to link biological outcomes to controllable variables; define CQAs/CPPs and operating ranges for scale-up/manufacturing readiness.
- Generate/interpret analytical readouts (RT-qPCR, intracellular flow cytometry, immunofluorescence imaging, ELISA, viability, metabolites, aggregate-size).
- Support standardized closed/semi-closed manufacturing-relevant workflows using single-use components and sterile/aseptic systems; maintain E-Lab documentation/SOPs/batch records; present data and propose next-step experiments; maintain safe, compliant lab environment.
Qualifications:
- Associate Scientist: BS/MS (bioengineering, chemical engineering, biology, stem cell biology, or related) with ~2–5+ years.
- Scientist: MS/PhD with ~3–8+ years.
- Hands-on human pluripotent stem cell culture (2D + 3D aggregate/suspension) and directed differentiation experience in scalable/process-development settings.
- Bioreactor experience (setup/sampling/monitoring/control); experience with assays (flow cytometry, RT-qPCR, imaging, ELISA, etc.).
- Ability to analyze data, troubleshoot variability, and translate findings into process recommendations.
- Strong documentation and communication; able to work independently with cross-functional partners.
Benefits:
- Approx. $115,000–$150,000/year depending on level/experience.
- Annual performance bonus; medical/dental/vision; 401K match; 20+ days PTO/year (prorated).
Preferred:
- US work authorization.
- Execute iPSC maintenance, scale-up preparation, 3D aggregate culture, and directed differentiation toward pancreatic islet-like cell populations.
- Design, run, and troubleshoot suspension-based differentiation experiments in scalable formats (including PBS Vertical Wheel bioreactors when appropriate).
- Operate controlled bioreactor systems and monitor inputs (pH, dissolved oxygen, agitation, inoculation density, feeding strategy, media exchange, culture timing).
- Innovate across workflow: signaling timing; growth factor/cytokine conditions; media/feed strategies; aggregate handling; cryopreservation/recovery; and culture-format changes to improve cell fate, scalability, and performance.
- Develop and optimize process parameters to improve endocrine commitment, beta cell identity, reproducibility, recovery, cryopreservation compatibility, and scalability.
- Apply Quality by Design and DOE to link biological outcomes to controllable variables; define CQAs/CPPs and operating ranges for scale-up/manufacturing readiness.
- Generate/interpret analytical readouts (RT-qPCR, intracellular flow cytometry, immunofluorescence imaging, ELISA, viability, metabolites, aggregate-size).
- Support standardized closed/semi-closed manufacturing-relevant workflows using single-use components and sterile/aseptic systems; maintain E-Lab documentation/SOPs/batch records; present data and propose next-step experiments; maintain safe, compliant lab environment.
Qualifications:
- Associate Scientist: BS/MS (bioengineering, chemical engineering, biology, stem cell biology, or related) with ~2–5+ years.
- Scientist: MS/PhD with ~3–8+ years.
- Hands-on human pluripotent stem cell culture (2D + 3D aggregate/suspension) and directed differentiation experience in scalable/process-development settings.
- Bioreactor experience (setup/sampling/monitoring/control); experience with assays (flow cytometry, RT-qPCR, imaging, ELISA, etc.).
- Ability to analyze data, troubleshoot variability, and translate findings into process recommendations.
- Strong documentation and communication; able to work independently with cross-functional partners.
Benefits:
- Approx. $115,000–$150,000/year depending on level/experience.
- Annual performance bonus; medical/dental/vision; 401K match; 20+ days PTO/year (prorated).
Preferred:
- US work authorization.