Associate Scientist II, Process Sciences

Role Summary

The successful candidate will be responsible for process development, process characterization and scale-up of small molecules and oligonucleotide drug candidates. The candidate will work closely with cross-functional teams and contract manufacturing organizations on process development, process transfer and oversight of manufacturing processes.

Responsibilities

• Design and conduct laboratory experiments, analyze results, and draw meaningful conclusions.
• Support Synthesis and downstream processing method optimization.
• Execution of oligonucleotide synthesis and downstream processes to provide the research and in-house non-GMP material in a tight timeline.
• Execution of in-process analytical tests.
• Participate in creating and reviewing SOPs and batch records in support of the in-house non-GMP manufacture.
• Oligonucleotide manufacturing, process development, optimization and scale up.
• Operation and optimization of downstream processing.
• Manufacturing of oligonucleotide APIs in a cGLP environment.
• Operation of analytical instruments and application of analytical techniques.

Qualifications

• BS in Chemical Engineering or Chemistry with 1-3 years lab experience, preferably in an industrial setting.
• Basic understanding of analytical techniques (pH, osmolality, conductivity measurement, HPLC, LC-MS etc.). Related hands-on experience is preferred.
• Knowledge of oligonucleotide manufacture process including phosphoramidite chemistry, Synthesis, chromatography, ultrafiltration etc. is a plus.
• Experience in record-keeping and excellent laboratory documentation practice, are required. Strong commitment to high laboratory and scientific standard.