Associate Scientist, Analytical Development
Bristol Myers Squibb
June 26, 2026
On-site
Cambridge, MA
Operations
Position: Associate Scientist, Analytical Development
Responsibilities
- Design and execute related bioanalytical experiment steps to advance analytical development objectives.
- Develop, optimize, qualify, and validate ELISA and cell-based assays (potency, binding, reporter gene) for Process Development and CMC.
- Generate, analyze, and interpret complex analytical data; prepare assay reports, protocols, SOPs, and technical documentation.
- Troubleshoot routine/non-routine assay issues; identify root causes and implement corrective actions.
- Perform routine analytical testing for characterization, stability, comparability, and release.
- Execute qualified/validated assays with accuracy, reproducibility, and traceability; document in ELN/LIMS.
- Review/verify data; escalate deviations/out-of-spec results; support method transfers and tech transfer.
- Manage critical reagents lifecycle (procure, qualify, characterize, store, inventory); conduct bridging/comparability studies.
- Maintain cell cultures (passaging, cryopreservation, thawing, mycoplasma testing), cell banks (working/master), and cell QC; troubleshoot cell culture issues.
- Drive continuous improvement and evaluate new analytical technologies.
- Provide technical leadership/mentorship; collaborate cross-functionally.
Qualifications (Required/Preferred)
- BS (5+ yrs) or MS (3+ yrs) or PhD (0–2 yrs) in Biochemistry/Biology/Analytical Chemistry/Immunology or related.
- Hands-on ELISA and cell-based assay development/execution.
- Experience with routine analytical testing, critical reagent lifecycle management, and regulated mammalian cell culture.
- ELISA platform knowledge (e.g., plate-based, MSD).
- Cell-based bioassay design (potency, cytotoxicity, proliferation, receptor-binding).
- Critical reagent qualification and GxP assay validation knowledge (ICH/USP/FDA).
- Statistical software (e.g., SoftMax Pro, GraphPad Prism, JMP) and LIMS/ELN experience preferred.
- GMP/GLP biologics/biosimilar experience preferred.
Benefits (as stated)
- Health coverage (medical, pharmacy, dental, vision); wellbeing programs; 401(k), disability and life insurance.
- Paid time off: flexible time off (US exempt) or 160 hours annual vacation (Phoenix/Puerto Rico/Rayzebio non-exempt/hourly), plus national holidays.
Working Conditions
- Laboratory-based; use of analytical instruments, biosafety cabinets, and cell culture facilities; occasional scheduling flexibility may be needed.
Responsibilities
- Design and execute related bioanalytical experiment steps to advance analytical development objectives.
- Develop, optimize, qualify, and validate ELISA and cell-based assays (potency, binding, reporter gene) for Process Development and CMC.
- Generate, analyze, and interpret complex analytical data; prepare assay reports, protocols, SOPs, and technical documentation.
- Troubleshoot routine/non-routine assay issues; identify root causes and implement corrective actions.
- Perform routine analytical testing for characterization, stability, comparability, and release.
- Execute qualified/validated assays with accuracy, reproducibility, and traceability; document in ELN/LIMS.
- Review/verify data; escalate deviations/out-of-spec results; support method transfers and tech transfer.
- Manage critical reagents lifecycle (procure, qualify, characterize, store, inventory); conduct bridging/comparability studies.
- Maintain cell cultures (passaging, cryopreservation, thawing, mycoplasma testing), cell banks (working/master), and cell QC; troubleshoot cell culture issues.
- Drive continuous improvement and evaluate new analytical technologies.
- Provide technical leadership/mentorship; collaborate cross-functionally.
Qualifications (Required/Preferred)
- BS (5+ yrs) or MS (3+ yrs) or PhD (0–2 yrs) in Biochemistry/Biology/Analytical Chemistry/Immunology or related.
- Hands-on ELISA and cell-based assay development/execution.
- Experience with routine analytical testing, critical reagent lifecycle management, and regulated mammalian cell culture.
- ELISA platform knowledge (e.g., plate-based, MSD).
- Cell-based bioassay design (potency, cytotoxicity, proliferation, receptor-binding).
- Critical reagent qualification and GxP assay validation knowledge (ICH/USP/FDA).
- Statistical software (e.g., SoftMax Pro, GraphPad Prism, JMP) and LIMS/ELN experience preferred.
- GMP/GLP biologics/biosimilar experience preferred.
Benefits (as stated)
- Health coverage (medical, pharmacy, dental, vision); wellbeing programs; 401(k), disability and life insurance.
- Paid time off: flexible time off (US exempt) or 160 hours annual vacation (Phoenix/Puerto Rico/Rayzebio non-exempt/hourly), plus national holidays.
Working Conditions
- Laboratory-based; use of analytical instruments, biosafety cabinets, and cell culture facilities; occasional scheduling flexibility may be needed.