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Associate Principal Scientist, Health Economic and Decision Sciences

Merck
August 24, 2026
Remote friendly (West Point, PA)
United States
Market Access
Role: Under the direction of an HEDS Senior Director, the Associate Principal Scientist provides strategic development and use of predictive and economic models to enhance understanding of disease and quantify/communicate the value of oncology products to patients, providers, and payers.

Responsibilities:
- Serve as the BARDS-HEDS lead for one or more Value and Implementation teams to develop health economic, disease, and predictive models for product business insights.
- Use discovery, real-world evidence, clinical trial and published data, and public tools to build economic and integrated models to answer key questions across drug/vaccine development (Phase I through loss of data exclusivity).
- Advance integrated quantitative approaches using economic, disease, predictive modeling and simulation with internal and external partners.
- Develop and maintain global health economic models and tools in-house or with external vendors to demonstrate product value.
- Support and train HEDS models/tools for country/regional adaptations and external stakeholder communications.
- Disseminate health economic data via congress presentations and scientific journal publications.
- Collaborate with external collaborators (clinical/economic thought leaders, payer/HTA experts, alliance partners) and internal cross-functional teams to apply new methodologies/models/analytics.
- Stay current on external data, modeling methodologies, and IT tools to enhance capabilities in health economic modeling, simulation, and data visualization.
- Share work products and best practices across the enterprise.

Education:
- PhD (preferred) or Master’s degree in Health Economics, Biostatistics, Health Services Research, Actuarial Sciences, Operations Research, or related quantitative field.

Required Experience/Skills:
- HEOR experience beyond degree.
- Knowledge/experience in economic evaluation of oncology drugs and interventions.
- Hands-on experience conceiving/designing/developing/disseminating health economic model approaches.
- Track record of HTA submissions and peer-reviewed/conference publications.
- Strong interpersonal, organizational, and communication skills.
- Understanding of market access environment in US and key international markets.

Required skills: Data Management, Economic Modeling, Health Economics, Health Economics Evaluation, Health Technology Assessment (HTA), Oncology, Stakeholder Relationship Management, Strategic Planning.

Application instructions:
- Apply through https://jobs.merck.com/us/en (or Workday Jobs Hub for current employees). Requisition ID: R413148.