Advisor/Senior Advisor, Purification Development - Bioconjugates

Role Summary

Advisor/Senior Advisor, Purification Development - Bioconjugates is a scientist role in the Purification Development group focused on downstream drug substance processes for biologics including monoclonal antibodies, bioconjugates, and related proteins. The role emphasizes purification technology development, process design, and tech transfer to GMP manufacturing, with strong collaboration across safety, quality, regulatory, and manufacturing functions.

Responsibilities

• Identify and develop new purification technologies
• Design optimized downstream drug substance processes for new biologic candidates with particular focus on complex bioconjugates
• Maintain accurate records and interpret data to provide detailed information and analysis on the execution of experiments
• Oversee process and technical transfer to GMP manufacturing facilities as projects move from discovery to the clinic
• Write technical reports, tech transfer documents and give presentations to summarize development activities
• Maintain flexibility to accept new projects and challenges
• Troubleshoot issues as they occur and identify trends to reduce process variability

Qualifications

• PhD in Chemical Engineering or related degree focused on biological separation sciences OR
• MS in Chemistry, Chemical Engineering, or related degree with at least 5 years relevant experience in leading protein purification/process development OR
• BS in Chemistry, Chemical Engineering, or related degree with at least 8 years relevant experience in leading protein purification/process development
• Hands-on experience with bioconjugate purification

Additional Preferences

• Attention to detail and a quality-minded approach to experimental design and record keeping
• Effective oral and written communication skills
• Strong laboratory skills
• Experience developing, optimizing, scaling, and tech transferring conjugation reactions for mAbs or other proteins (e.g., PEGylation, ADCs, antibody-oligonucleotide conjugates)
• Experience with bioconjugate purification challenges including maintaining conjugate stability and separating conjugated from unconjugated species
• Understanding of conjugation chemistry mechanisms and their impact on downstream purification strategies
• Purification development experience with AAV, mRNA, or other gene therapy strategies
• Ability to interact with a wide range of groups
• Experience with process control and documentation systems (Unicorn, Empower, electronic lab notebooks)
• Interpersonal and communication skills; mentoring, feedback, training, and fostering learning
• Basic analytical skills and advanced problem-solving abilities

Skills

• Scientific reasoning and data analysis
• Technical writing and presentation
• Cross-functional collaboration
• Process development and tech transfer
• Bioconjugate chemistry and purification techniques

Education

• PhD or equivalent in Chemical Engineering or related field; or MS/BS with relevant industry experience as outlined in Basic Requirements

Additional Requirements

• Physical demands are consistent with a lab environment
• Travel expectations not specified beyond typical lab environment requirements