Advisor - Biochemistry Lead
Eli Lilly and Company
September 03, 2026
On-site
Pasadena, CA
Clinical Research and Development
Responsibilities:
- Lead macrocyclic discovery biochemistry efforts; provide assay strategy for individual projects.
- Lead molecule testing from lead identification through lead optimization; contribute through Phase 1 and beyond.
- Provide assay development expertise for macrocyclic peptide discovery.
- Develop methodologies/protocols and run protein binding assays for compound characterization.
- Characterize protein reagent functionality; provide oversight into quality and tracking of reagents.
- Enhance Protomer platform assay/biochemical workflows (including automation).
- Collaborate cross-functionally; apply independent scientific rationale to strategy/execution.
- Prioritize assay efforts for high-conviction targets at Protomer and with the wider R&D organization.
- Maintain proactive safety culture and work professionally across Protomer and Lilly.
Minimum Qualifications:
- PhD in biochemistry, molecular biology, biology, chemical biology, or related field; postdoc experience a plus; research success track record.
- At least 1 year postdoctoral or industry experience in biochemistry/biophysics development.
- Expertise in protein expression and characterization (purification, functional characterization, protein biochemistry methods).
- Knowledge of oral macrocyclic peptides; peptide/protein properties and solubility; standardized permeability assays.
Additional Skills/Preferences:
- Experience on therapeutic targets with multiple modalities including macrocycles.
- Molecular biology knowledge.
- Experimental design, assay execution, troubleshooting, data analysis/interpretation.
- Lab automation systems; basic AI/ML knowledge is a plus.
- Drug discovery process knowledge (lead generation/optimization; partner with ADME, nonclinical safety, PK/PD).
- Clear communication; problem-solving, attention to detail, learning agility; drive continuous improvement.
Additional Information:
- Some domestic/international travel anticipated.
- Must be on site five days/week in Pasadena, CA.
- Lead macrocyclic discovery biochemistry efforts; provide assay strategy for individual projects.
- Lead molecule testing from lead identification through lead optimization; contribute through Phase 1 and beyond.
- Provide assay development expertise for macrocyclic peptide discovery.
- Develop methodologies/protocols and run protein binding assays for compound characterization.
- Characterize protein reagent functionality; provide oversight into quality and tracking of reagents.
- Enhance Protomer platform assay/biochemical workflows (including automation).
- Collaborate cross-functionally; apply independent scientific rationale to strategy/execution.
- Prioritize assay efforts for high-conviction targets at Protomer and with the wider R&D organization.
- Maintain proactive safety culture and work professionally across Protomer and Lilly.
Minimum Qualifications:
- PhD in biochemistry, molecular biology, biology, chemical biology, or related field; postdoc experience a plus; research success track record.
- At least 1 year postdoctoral or industry experience in biochemistry/biophysics development.
- Expertise in protein expression and characterization (purification, functional characterization, protein biochemistry methods).
- Knowledge of oral macrocyclic peptides; peptide/protein properties and solubility; standardized permeability assays.
Additional Skills/Preferences:
- Experience on therapeutic targets with multiple modalities including macrocycles.
- Molecular biology knowledge.
- Experimental design, assay execution, troubleshooting, data analysis/interpretation.
- Lab automation systems; basic AI/ML knowledge is a plus.
- Drug discovery process knowledge (lead generation/optimization; partner with ADME, nonclinical safety, PK/PD).
- Clear communication; problem-solving, attention to detail, learning agility; drive continuous improvement.
Additional Information:
- Some domestic/international travel anticipated.
- Must be on site five days/week in Pasadena, CA.