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VP, Program Management & Business Operations

Flagship Pioneering
August 26, 2026
Full-time
Remote friendly (Cambridge, MA)
Worldwide
Operations
Role: Senior leadership in program management and business operations for Alltrna's innovative tRNA therapeutics, focusing on early-stage drug development from research through IND enabling and clinical phases. Responsibilities: lead cross-functional program teams for the company's lead asset, AP003, ensuring strategic alignment, risk mitigation, and timely delivery; manage operational planning, resource allocation, and performance metrics; drive collaboration across scientific, clinical, and business functions; support strategic planning, communication, and partnership activities; serve as Chief of Staff and facilitate organizational efficiencies. Requirements: BS/MS in life sciences or chemistry; 15+ years in pharma/biotech drug discovery and development; 10+ years in program management, preferably in rare genetic diseases or advanced therapies; strong leadership, interpersonal, and communication skills; proven ability to manage complex programs and cross-disciplinary teams; passion for innovative medicines and digital approaches. HighValue: early-stage biotech, rare genetic diseases, IND-enabling, cross-functional leadership, strategic planning, program management, focus on novel modalities like engineered tRNA therapeutics, collaborative drug discovery. WorkSetup: not specified, but likely hybrid or onsite given leadership scope.