VP Medicine Development Leader- Oncology

Role Summary

The VP Medicine Development Leader (MDL) is responsible for strategically directing the global development of a medicine, serving as the single point of accountability from C2P2 to approval in the first major markets, with substantial input from pre-C2P2 to post-launch lifecycle management. The role defines the strategic vision and operational plan for the medicine, aligning it with the overall R&D strategy, and leads the matrix Medicine Development Team (MDT) across disciplines to deliver differentiated medicines of value.

Responsibilities

• Act as a single point of accountability in GSK for all aspects of a medicine in development globally from C2P2 to approval in first major markets.
• Provide key support to the Early Development Team (EDT) leading up to C2P2 to ensure smooth transfer of accountability and a successful C2P2 and transition from phase 1 to phase 2.
• Provide key support to the Medicines Commercialisation Team post-approval in first major markets ensuring MDT supports registration and lifecycle management.
• Select MDT members, lead the multi-disciplinary matrix team, support differentiated development for team members, own MDT performance and partner with line managers to drive performance.
• Establish a compelling vision for the medicine; position the medicine within the R&D strategy; translate strategy into asset strategy and actionable plans.
• Deliver differentiated medicines of value through an evidence package supporting regulatory approval, market access, and lifecycle.
• Deliver the Medicine Development Strategy aligned with the R&D disease strategy and asset Medicine Vision and Medicine Profile.
• Prioritize asset portfolio options, develop multiple indications, and make evidence-based go/no-go/accelerate decisions with clear inflection points.
• Embed core processes including cost efficiency, technology adoption, risk management, and policy compliance.
• Identify and align resources (people and financial) to ensure successful project completion.
• Proactively identify unmet medical needs addressable through line extensions and incorporate patient voice into development plans.
• Promote organizational reputation and asset value by engaging with internal and external stakeholders; share knowledge and best practices.
• Collaborate with EDLs and other MDLs to create strategies aligned with organizational vision; disseminate best practices.
• Ensure quality and compliance oversight per R&D expectations; assure data and scientific quality.
• Prioritize and manage asset portfolio options to meet budget constraints.
• Model values and leadership expectations; serve as asset spokesperson to senior management and governance committees as needed.
• Increase external visibility (physicians, regulators, patients, payers) to bring solutions to unmet medical needs and enhance GSK reputation.
• Act as the single accountable decision-maker to resolve MDT disputes; discuss misalignment with Head of Development before final decisions.
• Deliver and manage the asset resourcing plan and budget; develop ongoing patent strategy for the asset.
• Partner with Business Development to facilitate diligence, product positioning, and strategic decisions; engage in governance processes and alliance management as required.

Qualifications

• Required: Advanced degree in a clinical or scientific discipline (MD, PhD, PharmD or equivalent).
• Required: Filing experience with BLA/NDA/MAA submissions as a core responsibility and demonstrated leadership of development programs.
• Required: Extensive broad drug development expertise and experience; executive-level pharmaceutical industry experience; prior significant experience in leading successful development and registration of medicines; deep experience in product development and/or commercial, especially in late-phase Oncology development (from PoC onwards), with clinical trial management of high complexity, post-approval studies, regulatory and manufacturing compliance.
• Required: High ethics and integrity with sound medical decision-making skills.
• Required: Holistic understanding of R&D across development and commercial life cycle to impact discovery, late-stage development, regulatory, manufacturing, and commercial functions.
• Required: Proven ability to operate in highly complex, matrixed, global, multi-disciplinary organizations with high accountability and multiple reporting lines.
• Required: Experience working with regulators and understanding regulatory frameworks across global geographies.
• Required: Strong people management, leadership, and motivational skills.
• Required: Experience creating lifecycle strategy for pre- and post-marketing studies and driving lifecycle processes.
• Required: Ability to collaborate across functions—research, commercial, regulatory, global supply, legal, regions, etc.—and build authentic alignment while leading high-performing teams.
• Required: Thorough understanding of the healthcare environment and engagement with key external stakeholders.

• Preferred: Business acumen with experience managing a sizable P&L, budgeting, and strategic/budget planning.
• Preferred: Track record of leading with high operational complexity across globally dispersed, multi-disciplinary teams with high accountability and multiple reporting lines.
• Preferred: Willingness to apply and adapt leadership approach; inclusive and diverse to shape a medicine that could significantly impact patients.

Additional Requirements

• On-site presence required 2 to 3 days per week in the UK (London or Stevenage) or US (Collegeville/Upper Providence, PA or Waltham, MA).