VP, Global Trial Optimization

Role: Vice President, Global Trial Optimization, leading strategic feasibility, protocol optimization, scenario modeling, and patient recruitment across Alnylam's clinical development portfolio. Responsibilities: establish a Feasibility Center of Excellence, partner with CROs, develop data-driven scenario plans for country/site selection, optimize patient recruitment and retention strategies, and model trial timelines and enrollment impacts; lead governance discussions on trial delivery strategies. Qualifications: 20+ years in clinical operations, including global trial conduct, feasibility, and patient recruitment; 10+ years of team leadership; advanced degree (MSc, MBA, PhD) preferred; expertise in trial scenario planning, data analysis, Monte Carlo simulations, and regulatory compliance (ICH-GCP, FDA/EMA guidelines). HighValue: extensive experience with biopharma drug development, particularly in RNAi therapeutics or related modalities, with a focus on rare or unmet disease areas; proven ability to optimize trial performance, reduce costs, and manage cross-functional teams. WorkSetup: global role with up to 30% travel; reports to SVP, Pipeline Delivery; operates within a highly entrepreneurial biotech environment emphasizing collaboration, innovation, and scientific excellence.