Vice President, U.S. Market Access

Key Accountabilities / Core Job Responsibilities
- Lead U.S. market access strategy for Denali’s portfolio, including launch and post-launch optimization for AVLAYAH and future pipeline assets.
- Develop integrated payer engagement, coverage, reimbursement, and patient support strategies tailored to rare disease and specialty infusion/orphan markets.
- Shape access strategy for accelerated approval pathways and label expansion (e.g., sBLA, lifecycle management).
- Partner with Commercial leadership on go-to-market strategy (patient segmentation, site-of-care, provider access).
- Provide executive leadership for U.S. market access functions (payer field team, patient access/experience, pricing, contracting, channel operations/strategy, government price reporting).
- Lead payer/pricing/policy strategy: engage commercial and government payers; execute pricing/contracting (incl. gross-to-net and value-based where appropriate); navigate payer policies for gene/enzyme therapies, biomarkers, and surrogate endpoints; advise leadership on reimbursement risks.
- Evidence & value: define payer value proposition (clinical/biomarker/RWE); build HEOR models and access-focused evidence for coverage and AA-to-full conversion; ensure endpoints/RWE strategies are embedded in studies; support publication/value communication.
- Patient support: design HUB/prior authorization/affordability programs; ensure onboarding/therapy initiation; oversee compassionate use/early access; optimize patient experience.
- Trade/distribution/site-of-care: manage specialty pharmacy/distribution and site-of-care optimization; partner with supply chain to ensure access; align channel strategy to patient journey and payer needs.
- Operations/analytics: track access metrics (time-to-therapy, onboarding, payer approval rates); drive data-driven optimization; lead continuous improvement.
- Pipeline/global alignment: partner to assess access strategy for pipeline/external assets; scale infrastructure for global expansion; align U.S. access with global evidence/regulatory where appropriate.
- Lead and influence cross-functionally; serve as CMPA Leadership Team member and strategic advisor.

Qualifications / Skills
- Bachelor’s degree and 20+ years biotech/pharma experience; senior market access leadership; 15+ years people leadership. Advanced degree (MBA/MPH/PharmD/PhD) preferred.
- Deep U.S. payer/reimbursement expertise for specialty/orphan drugs.
- Strong biomarker-driven/surrogate endpoint understanding for payer acceptance.
- HEOR/RWE and value-based access experience.
- Strategic + hands-on execution; strong leadership, communication, and stakeholder management.
- Ability to operate in fast-paced, evolving environments; high integrity and compliance/patient-centric decision-making.
- Experience launching therapies in rare disease, neurology, or specialty markets.
- Strong experience with accelerated approval, lifecycle management, and evidence-based access strategies.
- Pre-commercial/emerging biotech experience preferred.