Vice President, Translational Medicine

Role Summary

Vice President of Translational Medicine at Janux Therapeutics. Lead the integration of clinical data across early development programs, synthesizing PK, PD, biomarkers, safety, efficacy, immunogenicity, and durability into an actionable framework to inform clinical strategy and decision-making.

Responsibilities

• Lead the hands-on integration of clinical data across modalities and endpoints to inform program strategy.
• Develop and communicate a data-driven narrative that connects mechanistic understanding with clinical outcomes.
• Translate complex datasets into clear recommendations for dose selection, trial design, and go/no-go decisions.
• Ensure translational insights are embedded in clinical protocols, regulatory filings, and development milestones.
• Partner with medical leads, clinical science, clinical operations, biomarker, regulatory, and safety teams to align translational strategy with program goals.
• Serve as a key contributor to governance and program teams, representing translational science in strategic discussions.
• Collaborate with external experts and CROs to support modeling, PK analysis, and specialized translational efforts.
• Lead and mentor a growing translational team, fostering a culture of scientific excellence and strategic thinking.
• Define and evolve the function‚Äôs capabilities, including biomarker strategy, clinical pharmacology, and data integration.
• Identify and manage external partnerships to complement internal expertise.
• Support regulatory interactions by providing integrated translational insights and data interpretation.
• Represent the company in scientific forums, advisory boards, and external collaborations.

Qualifications

• PhD, PharmD, or MD in pharmacology, immunology, translational science, or a related field.
• 12+ years of experience in translational medicine, clinical development, or related areas in biotech/pharma.
• Demonstrated ability to integrate and interpret complex clinical datasets into strategic program decisions from early clinical development to late-stage clinical trials.
• Strong understanding of PK/PD principles, biomarker development, and regulatory expectations.
• Experience with biologics, ADCs, or immunotherapies is highly desirable. Direct experience within oncology and autoimmune will be given priority.
• Exceptional communication skills, with the ability to translate science into strategy and influence cross-functional teams.
• Strong track record of contributing to regulatory submissions and engaging with global health authorities.
• Strong organizational and time management abilities.
• High level of accountability, adaptability, and attention to detail.
• Ability to work independently and collaboratively in a fast-paced, matrixed environment.
• Ability to travel up to 15%.

Location

On site (San Diego, CA)