Vice President, Portfolio Chemistry

Role: Vice President, Portfolio Chemistry, leading Revolution Medicines' medicinal chemistry and related sciences to advance oncology programs from hit validation through development candidate nomination. Responsibilities: develop and execute long-term chemistry strategy, integrate computational, AI/ML, and digital tools into discovery workflows, oversee organizational planning, resource allocation, and foster collaboration across research functions to ensure seamless program progression. Requirements: Ph.D. in Organic Chemistry; 16+ years in industrial drug discovery with proven leadership supporting multiple discovery programs; deep expertise in medicinal chemistry, structure-based design, and optimization; experience with computational chemistry and external collaborations. Preferred: oncology drug discovery experience, successful IND filings, clinical candidate delivery, patents/publications, experience with modalities like molecular glues or ADCs. High-value specifics: leadership in oncology small-molecule programs, from hit validation to IND-enabling studies, with experience integrating AI/ML into discovery. Collaboration with senior research leadership, external CROs, and cross-functional teams is essential. Work setup: onsite at Redwood City, CA, with salary range $294K-$367K, inclusive of competitive compensation, equity, and benefits.