Vice President, Medical Affairs - Skeletal (EDG-2025067)

Vice President, Medical Affairs - Skeletal

About Edgewise Therapeutics:

At Edgewise, we are on a mission to discover new medicines that improve the lives of patients facing serious muscle disease. Our intimate knowledge of muscle biology and biophysics along with our ability to identify and design muscle specific precision small molecules have enabled us to rapidly advance our skeletal muscle and cardiac muscle product candidates into the clinic while also building a robust pre-clinical pipeline. With this focus on therapeutics designed to protect and improve muscle health, our goal is to dramatically enhance the lives of people living with progressive muscle disorders.

We have assembled an experienced and highly motivated leadership team with a strong track record in the biotechnology and pharmaceutical industry to build the leading, global muscle disease biopharmaceutical company. Come join us make a significant difference in the lives of patients!

About the Position:

The Vice President, Medical Affairs is a senior leader responsible for shaping and executing the global Medical Affairs strategy across the organization, with a focus on scientific communications, evidence generation, stakeholder engagement, and operational excellence. Reporting to the Chief Medical Officer, the VP provides visionary leadership to cross-functional teams supporting neuromuscular diseases.

This individual will oversee a growing Medical Affairs organization, build out key capabilities and infrastructure, and serve as a key member of the R&D and senior leadership teams. The VP will lead the development of scalable processes to ensure scientific integrity, compliance, and alignment with corporate strategy, while also serving as a visible external-facing leader with KOLs, investigators, and advocacy groups.

Essential Job Duties and Functions:

• Provide strategic and operational leadership for the global Medical Affairs function, ensuring alignment with corporate goals and evolving portfolio needs.
• Oversee all aspects of scientific communications, including publication strategy, congress planning, and internal/external education.
• Build and scale the Medical Affairs function, including the development of key capabilities in scientific engagement and field medical strategy.
• Establish and maintain high-impact relationships with external stakeholders such as KOLs, investigators, healthcare organizations, and patient advocacy groups.
• Have a deep familiarity with the science of the therapeutic landscape.
• Lead the development and implementation of scientific platforms, core messaging, and communication tools to support clinical development and commercialization efforts.
• Partner with Clinical Development, Regulatory, Commercial, and Market Access to support integrated evidence generation, lifecycle planning, and strategic decision-making in a near commercial-environment.
• Ensure Medical Affairs operations are compliant, efficient, and aligned with global best practices, including oversight of budget, SOPs, and internal governance processes.
• Lead, mentor, and grow a high-performing Medical Affairs team, fostering a culture of excellence, collaboration, and accountability.
• Serve as a strategic advisor to the CMO and other senior executives, contributing medical insight to corporate strategy and investor communications.
• Read, understand, and comply with all workplace health and safety policies; safe work practices; and company policies and procedures.
• Perform other duties as assigned by supervisor.
  
  
  

Required Education, Experience and Skills:

• Advanced degree in medicine or life sciences (MD, PhD, PharmD, or equivalent) required.
• 15+ years of progressive Medical Affairs leadership experience within the pharmaceutical or biotechnology industry.
• Proven track record of senior management/executive-level leadership, including building and scaling medical affairs teams and infrastructure.
• Deep expertise in neuromuscular diseases preferred.
• Demonstrated excellence in medical affairs strategy, scientific communication, publication strategy, and external stakeholder engagement.
• Strong strategic and analytical thinking, with the ability to align medical objectives with broader business goals.
• Outstanding interpersonal, leadership, and influencing skills, with the ability to engage effectively across internal and external stakeholders.
• Experience managing complex budgets, external vendors, and global operational frameworks.
• Ability to thrive in a fast-paced, high-growth environment and drive organizational change.
  
  
  

Position Type/Expected Hours of Work:

This is a remote position with up to 25% travel.

Salary range: $300,000 - $375,000, title and salary commensurate with experience

Our Benefits: We are proud to offer health benefits, a discretionary bonus plan, stock option grants. a stock purchase plan, a 401(k) with match and paid time off to our team members as part of their compensation plan.

There is no deadline because the employer accepts applications on an ongoing basis.

Edgewise does not accept resumes from recruitment agencies for this position. Please do not send resumes to Edgewise employees or the company location. Edgewise is not responsible for any fees related to unsolicited resumes.