Vice President, Head of Cardiovascular Medicine

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Role Summary

Rocket is seeking a Vice President and Head of Cardiovascular Medicine to develop transformative cell- and gene-based therapies for rare and life-threatening disorders. The candidate will define the strategy and execution of innovative clinical studies with gene therapies for cardiomyopathy and related disorders, act as the lead study physician/medical director for at least one clinical study, collaborate with senior stakeholders to shape development strategy, and contribute to health-authority submissions and ultimately marketing authorization.

Responsibilities

• Reporting to the Chief Medical Officer, the Vice President and Head of Cardiovascular Medicine role will involve intense collaboration with academic investigators/scientific experts to support clinical trials program.
• Along with other responsibilities, the candidate would be responsible end to end, for at least one of the clinical development programs as lead physician, with adherence to GCP guidelines and other relevant health authority regulations.
• Develop and share expertise in the science of various gene therapies in development and the patho-physiologies that occur with genetic variants to permit leading internal and external discussions of strategic approaches to company’s novel therapeutic approaches.
• Develop and advise on clinical protocols for studies as appropriate for ongoing and future development activities.
• Serve as the primary clinical contributor for trial related documentation, protocols and regulatory submissions
• Participate in clinical advisory boards in collaboration with Medical Affairs and cross functional team, steering committees and data safety monitoring boards as required.
• Reviews all medical/scientific publications related to clinical, translational or pre-clinical studies keeping the R&D and BD teams informed, as appropriate.
• Develop imaging and blood biomarkers strategy for cardiac dysfunction and the effects of therapeutic interventions with various agents.
• Provide expert advice on setting up study related databases to capture appropriate cardiac related data points.

Qualifications

• MD or DO with at least 10 years of progressive leadership experience in cardiovascular diseases and clinical research in a clinical/ industry setting is required. Certification or substantial clinical experience in Advanced Heart Failure and Familial/Genetic Cardiomyopathy is highly desirable.
• Deep knowledge of GCPs governing the conduct of clinical trials; working knowledge of the FDA, the EMA and other health authorities Regulations and ICH Guidelines.
• Deep understanding of science and genetics underlying cardiomyopathy and heart failure
• Demonstrated success leading cardiovascular clinical programs, with experience in global trial execution and regulatory submissions strongly preferred
• Proven ability to lead and influence cross-functional teams. Familiarity with innovative imaging technologies in cardiovascular disease research, such as echocardiography, magnetic resonance imaging, positron emission tomography, and novel or established cell signaling systems.
• Must have ability to work collaboratively as part of a multi-functional drug development team in a dynamic environment.
• Must be self-motivated, highly organized, detail-oriented and able to multi-task, delivering high quality work.
• Excellent oral and written communication skills; excellent interpersonal skills, including the ability to influence and to work effectively cross-culturally and cross-functionally.
• Ability to travel 15-20% of the time is required for investigator meetings/ medical conferences, etc.