Vice President, Gene Editing Core

Role Summary

The Vice President, Gene Editing Core leads a cross-functional team applying state-of-the-art genomic and molecular biology tools to advance genome editing therapies. This role oversees the planning, execution, and delivery of early research and development projects, developing assays and reagents to characterize gene editing outcomes including on- and off-target effects and structural variant assessment. It drives platform improvements and novel nucleases into therapeutic programs, leads genomics and RNA labs, and manages gene editing analysis technologies and component production, collaborating with project teams to advance discovery projects toward development candidates while fostering a culture of collaboration and innovation and adopting new technologies as needed.

Responsibilities

• Strategic Planning and Leadership: Creates and leads vision of genomics innovation to support research in developing gene-editing therapies
• Collaborates across Platform Innovation and Delivery Innovation to advance novel nucleases, insertion strategies, new technologies, delivery advancements, and develop assays to assess the potential for unintended genomic changes
• Supports Screening efforts generating data in support of advancing the pipeline programs and platform improvements including guide RNA, messenger RNA, and delivery optimization as well as novel nuclease advancement
• Oversees NGS production efforts, running AMP-seq, off-target discovery, off-target confirmation, and structural variant analysis
• Collaborates with Pre-Clinical NGS for assay transfer, validation, and scale-up
• Partners with computational biology, software engineering, and automation on data analysis, data capture, and workflow optimization
• Evaluates and adopts new technologies and platforms to improve methods and technology in support of the company’s strategic direction
• Oversees the budget and resource allocation of the Genomics Core, including equipment purchases, ensuring timely delivery of services across all relevant company projects
• Ensures proper documentation, sample tracking, compliance with regulations, guidelines, and standards related to genomic research, data management, and biosafety protocols
• Communicates with users, providing guidance, and bringing in external consultant and collaborators as needed
• Works with clinical, regulatory, and product development teams to integrate gene editing and genomics insights into workflows, and other business processes
• Serves as a functional representative for program teams, providing expertise and guidance on gene editing methods to support development candidate nomination and regulatory filing
• Fosters a culture of collaboration, innovation, teamwork, and communication, and handle discipline and termination of employees in accordance with company policy

Qualifications

• Extensive experience in genomics, including sequencing technologies and genomic data analysis
• Familiarity with industry regulations and standards related to genomic research and data management
• Experience with various genomic technologies, including NGS, ddPCR, single-cell genomics, and spatial transcriptomics
• Strong foundation in experimental design and bioinformatics: ability to design experiments, analyze data, and interpret results
• Leadership and management: proven experience leading a team of core function scientists and managing multiple projects, with oversight of laboratory operations
• Communication and collaboration: excellent communication and interpersonal skills for cross-functional teamwork
• Regulatory knowledge: familiarity with relevant regulatory standards and guidelines
• Problem-solving and analytical skills: ability to analyze complex problems, identify solutions, and implement them effectively
• Industry knowledge: deep understanding of the biopharma industry and its trends, including preclinical and clinical research
• Ability to work in a fast-paced environment and prioritize multiple tasks and projects

Education

• PhD or equivalent in a relevant field such as molecular biology, biochemistry, or genomics
• Experience requirements: PhD holders typically require 8+ years of related professional experience; master's or bachelor's degree holders require 10+ years; and at least 7+ years of direct people management experience