Vice President, Early-Stage Clinical Development

Role Summary

Vice President, Early-Stage Clinical Development responsible for strategy and execution of early development activities across Alto’s portfolio, spanning toxicology, clinical pharmacology, and translational studies. Provides high-level scientific direction and hands-on operational oversight to advance programs efficiently and compliantly, bridging discovery science and clinical proof-of-concept.

Responsibilities

• Lead integrated early development strategy and execution for all pipeline assets.
• Design and oversee IND-enabling and early clinical studies.
• Partner cross-functionally to align development, regulatory, and operational plans.
• Manage CRO and vendor relationships for quality, speed, and cost efficiency.
• Build and mentor a growing early development team.
• Represent Alto with regulators, advisors, and external collaborators.
• Ensure compliance with applicable regulations, guidelines, and standards (e.g., GxP, ICH, FDA/EMA expectations) as well as Alto’s internal quality systems and SOPs.

Qualifications

• Advanced Degree (MD, PhD, or PharmD) with 10+ years in drug development.
• Proven success leading IND-enabling and early-phase studies in biotech or pharma.
• Deep expertise in toxicology, clinical pharmacology, and translational science.
• Strong leadership, communication, and cross-functional collaboration skills.
• Thrives in a dynamic, fast-paced, mission-driven environment.

Location

Mountain View, CA or Remote