Vice President - Early Detection Informatics
Caris Life Sciences
12 hours ago
On-site
Tempe, AZ
IT
Position Summary
Vice President, Early Detection Informatics provides senior leadership for early cancer detection data science and bioinformatics initiatives supporting blood-based, multi-analyte diagnostic technologies. Oversees the production informatics environment, bioinformatics pipeline orchestration, maintenance, support, and advanced analytics while owning strategy and execution for scalable, production-grade computational systems.
Job Responsibilities
- Executive oversight for design, implementation, reliability, and scalability of bioinformatics and data engineering pipelines integrating sequencing platforms, lab systems, and clinical data.
- Oversee development, orchestration, and production deployment of bioinformatics workflows supporting early detection assays.
- Establish and enforce canonical data models, metric definitions, dataset versioning, and change control across research, validation, and production.
- Ensure data integrity, auditability, traceability, and compliance with GxP and regulatory expectations.
- Define and implement cloud-based or hybrid compute strategies for high-throughput analysis, reproducible execution, and model retraining.
- Own SLAs, uptime targets, monitoring/alerting, and assay turnaround time for production pipelines supporting clinical reporting.
- Build, mentor, and lead a high-performing informatics and bioinformatics team.
- Set goals/OKRs, budgets, roadmaps, and operating cadence aligned to corporate and regulatory priorities.
- Establish governance models, performance metrics, and stakeholder engagement frameworks.
- Champion scientific rigor, accountability, transparency, data integrity, and continuous improvement.
Required Qualifications
- PhD in Data Science, Bioinformatics, Biostatistics, Computer Science, Biomedical Engineering, or related field.
- 10+ years building and operating production-grade analytics or bioinformatics solutions in diagnostics/medical devices/pharma/high-throughput labs.
- Expert in Python, SQL, ETL/ELT, orchestration, APIs, and scalable workflows.
- Extensive bioinformatics pipeline and NGS (including Illumina) experience.
- Regulated environment experience with GxP, CLIA, CAP, and FDA quality systems.
- Leadership experience managing technical teams for large-scale, cross-functional delivery.
- Proficient in Microsoft Office (Word, Excel, Outlook, PowerPoint).
- Onsite role in Phoenix, AZ with regular in-person presence.
Preferred Qualifications
- DRAGEN workflows; advanced sequencing analytics.
- AWS (SageMaker, S3, Athena); familiarity with AWS HealthOmics.
- Integration of LIMS, instruments, MES/LES, environmental monitoring.
- Knowledge of ISO 13485, 21 CFR 820, MDSAP, IVDR (data/documentation).
- Enterprise dashboarding, data modeling/governance, performance optimization, advanced analytics.
Vice President, Early Detection Informatics provides senior leadership for early cancer detection data science and bioinformatics initiatives supporting blood-based, multi-analyte diagnostic technologies. Oversees the production informatics environment, bioinformatics pipeline orchestration, maintenance, support, and advanced analytics while owning strategy and execution for scalable, production-grade computational systems.
Job Responsibilities
- Executive oversight for design, implementation, reliability, and scalability of bioinformatics and data engineering pipelines integrating sequencing platforms, lab systems, and clinical data.
- Oversee development, orchestration, and production deployment of bioinformatics workflows supporting early detection assays.
- Establish and enforce canonical data models, metric definitions, dataset versioning, and change control across research, validation, and production.
- Ensure data integrity, auditability, traceability, and compliance with GxP and regulatory expectations.
- Define and implement cloud-based or hybrid compute strategies for high-throughput analysis, reproducible execution, and model retraining.
- Own SLAs, uptime targets, monitoring/alerting, and assay turnaround time for production pipelines supporting clinical reporting.
- Build, mentor, and lead a high-performing informatics and bioinformatics team.
- Set goals/OKRs, budgets, roadmaps, and operating cadence aligned to corporate and regulatory priorities.
- Establish governance models, performance metrics, and stakeholder engagement frameworks.
- Champion scientific rigor, accountability, transparency, data integrity, and continuous improvement.
Required Qualifications
- PhD in Data Science, Bioinformatics, Biostatistics, Computer Science, Biomedical Engineering, or related field.
- 10+ years building and operating production-grade analytics or bioinformatics solutions in diagnostics/medical devices/pharma/high-throughput labs.
- Expert in Python, SQL, ETL/ELT, orchestration, APIs, and scalable workflows.
- Extensive bioinformatics pipeline and NGS (including Illumina) experience.
- Regulated environment experience with GxP, CLIA, CAP, and FDA quality systems.
- Leadership experience managing technical teams for large-scale, cross-functional delivery.
- Proficient in Microsoft Office (Word, Excel, Outlook, PowerPoint).
- Onsite role in Phoenix, AZ with regular in-person presence.
Preferred Qualifications
- DRAGEN workflows; advanced sequencing analytics.
- AWS (SageMaker, S3, Athena); familiarity with AWS HealthOmics.
- Integration of LIMS, instruments, MES/LES, environmental monitoring.
- Knowledge of ISO 13485, 21 CFR 820, MDSAP, IVDR (data/documentation).
- Enterprise dashboarding, data modeling/governance, performance optimization, advanced analytics.