Vice President, Clinical Operations
4D Molecular Therapeutics
August 18, 2026
Remote friendly (United States)
United States
Operations
Vice President, Clinical Operations (Reporting to Chief Clinical Operations Officer)
Major Duties and Responsibilities:
- Provide operational leadership and oversight for one or more large global clinical programs or multiple phase 1–2 studies from start-up through database lock.
- Ensure trials are executed on time, to quality standards, within budget, and aligned to corporate objectives.
- Lead Clinical Operations teams to identify risks, develop mitigation plans, and resolve operational challenges; maintain inspection readiness.
- Drive study performance using key operational metrics and continuous improvement.
- Lead, mentor, and develop Clinical Operations leaders (Senior Directors, Directors, CTMs).
- Partner cross-functionally (Clinical Science, Medical, Regulatory, Data Sciences, Clinical Compliance, Quality, Pharmacovigilance, Technical Operations) to ensure seamless execution.
- Provide executive oversight of CROs and strategic vendors; establish risk-proportionate sponsor oversight and ensure documented escalation and performance/compliance evaluation.
- Oversee study budgets, forecasts, change orders, and resource planning.
- Drive inspection readiness and ensure adherence to GCP, SOPs, regulatory requirements, and quality standards.
Core Competencies / Skills:
- Leading execution of complex global Phase 1–3 trials; manage concurrent programs.
- Systems thinking; scalable process design; use of dashboards/analytics to drive decisions.
- Process improvement experience to increase efficiency/quality/predictability.
- Influence cross-functional teams without direct authority; executive communication.
- Knowledge of ICH-GCP and global clinical trial regulations (FDA/EMA).
Qualifications:
- Bachelor’s degree in scientific, business, or health-related discipline.
- 15+ years Clinical Operations experience in biotechnology/pharma.
- Significant experience leading global Phase 1–2 and/or Phase 3 trials.
- Experience supporting regulatory authority inspections.
- 6+ years people leadership (managing senior Clinical Operations leaders).
- Ophthalmology (retina) clinical development experience strongly preferred.
Travel: 5%
Major Duties and Responsibilities:
- Provide operational leadership and oversight for one or more large global clinical programs or multiple phase 1–2 studies from start-up through database lock.
- Ensure trials are executed on time, to quality standards, within budget, and aligned to corporate objectives.
- Lead Clinical Operations teams to identify risks, develop mitigation plans, and resolve operational challenges; maintain inspection readiness.
- Drive study performance using key operational metrics and continuous improvement.
- Lead, mentor, and develop Clinical Operations leaders (Senior Directors, Directors, CTMs).
- Partner cross-functionally (Clinical Science, Medical, Regulatory, Data Sciences, Clinical Compliance, Quality, Pharmacovigilance, Technical Operations) to ensure seamless execution.
- Provide executive oversight of CROs and strategic vendors; establish risk-proportionate sponsor oversight and ensure documented escalation and performance/compliance evaluation.
- Oversee study budgets, forecasts, change orders, and resource planning.
- Drive inspection readiness and ensure adherence to GCP, SOPs, regulatory requirements, and quality standards.
Core Competencies / Skills:
- Leading execution of complex global Phase 1–3 trials; manage concurrent programs.
- Systems thinking; scalable process design; use of dashboards/analytics to drive decisions.
- Process improvement experience to increase efficiency/quality/predictability.
- Influence cross-functional teams without direct authority; executive communication.
- Knowledge of ICH-GCP and global clinical trial regulations (FDA/EMA).
Qualifications:
- Bachelor’s degree in scientific, business, or health-related discipline.
- 15+ years Clinical Operations experience in biotechnology/pharma.
- Significant experience leading global Phase 1–2 and/or Phase 3 trials.
- Experience supporting regulatory authority inspections.
- 6+ years people leadership (managing senior Clinical Operations leaders).
- Ophthalmology (retina) clinical development experience strongly preferred.
Travel: 5%