Madrigal

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

VP, Clinical Development Program Leader

The VP, Clinical Development Program Leader for SYH2086 will play a key role as an integrative driver, with full accountability for all cross-functional project deliverables. This hybrid role blends strategic clinical leadership with cross-functional program oversight, ensuring seamless integration of clinical development, biostatistics, operations, CMC, regulatory, and safety functions for SYH2086. This is a high-impact leadership role for a dynamic clinical expert who excels at integrating scientific, operational, and strategic thinking to drive successful program outcomes. The role is expected to evolve from direct responsibility for Phase 1 clinical execution to building and leading a team accountable for delivering the full clinical development program through to registration. This includes continued cross-functional matrix leadership throughout the development lifecycle.

Responsibilities

• Lead the cross-functional Program Team for SYH2086, shaping product strategy and driving the creation and execution of an integrated development plan. As the program advances, expand leadership responsibilities from hands-on early-phase execution to oversight of a team delivering the full clinical program.
• Transition from direct clinical oversight in early development to strategic leadership of a growing clinical team, ensuring continuity and excellence across all phases of development.
• Serve as the accountable physician and program lead, with strong clinical oversight while managing contributions from key functional representatives including Biostats, Regulatory, Safety, and Operations.
• Drive strategic alignment by setting program goals in collaboration with executive leadership and ensuring they are consistently understood and supported across functions.
• Ensure clear definition of deliverables, maintain accountability for program timelines and budget, and align activities with portfolio management and internal reporting needs.
• Stimulate informed decision making by fostering robust cross-functional collaboration, identifying opportunities, addressing challenges, and mitigating risks through scenario planning and contingency strategies.
• Foster a culture of openness and trust, building strong relationships across departments to facilitate transparent communication, issue resolution, and unified problem-solving.
• Contribute to business case development, regularly updating the Target Product Profile (TPP) in collaboration with Commercial, Market Access, Clinical, and Regulatory stakeholders.
• Report program strategy, risks, and progress to senior management, ensuring transparency, clarity, and alignment at all levels of the organization.

Requirements

• 15+ years of experience in medical, clinical or drug development, including 10+ years in senior leadership roles with a strong record of cross-functional and global program leadership.
• Proven success in leading clinical programs across all development phases, including late-stage, regulatory filings (INDs/NDAs/BLAs), launch, and commercialization.
• Extensive experience working in matrixed, global teams, with the ability to influence across functions without direct reporting lines.
• Demonstrated ability to interface with regulatory authorities and contribute to health authority submissions in collaboration with regulatory, CMC, and commercial teams.
• Strong strategic thinking and business acumen, with the ability to make sound, data-informed decisions in complex and ambiguous situations.
• Skilled in stakeholder management, including engagement with senior leadership, and in presenting complex program strategies to drive executive decision-making.
• Excellent verbal and written communication, with advanced influencing, negotiation, and conflict resolution skills.
• Deep understanding of the commercial landscape, regulatory strategy, and CMC considerations relevant to drug development.
• Knowledgeable in budget and financial management practices within the pharmaceutical industry.
• Recognized for leading high-performing, collaborative teams in dynamic and fast-paced environments.
• Highly ethical, with strong personal credibility and leadership, fostering a culture of trust, integrity, and respect.
• Adept at making informed decisions with incomplete data, balancing risk and opportunity while maintaining focus on program goals.

Education

• MD or Ph.D.

Location

Hybrid working 3 days in office per week located in Conshohocken, PA.

Compensation

Base salary is determined by several factors that include, but are not limited to, a successful candidate's qualifications, skills, education, experience, business needs, and market demands. The role may also be eligible for bonus, equity, and comprehensive benefits, which include flexible paid time off (PTO), medical, dental, vision, and life and disability insurance.

Equal Opportunity Employer

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.

Agency Submissions

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.

Fraud Notice

Please be aware that we are currently receiving numerous reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process. Interviews with Madrigal are conducted via the Zoom platform.

Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for Madrigal we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks.