Vice President, Clinical Development

Role Summary

Tango Therapeutics is seeking an experienced oncologist to serve as Vice President Clinical Development for our PRMT5 programs in development for MTAP-deleted cancers. This strategic leadership role will drive clinical development strategy and execution as we advance into Phase 3 development. You will serve as the clinical and scientific voice for the program. This role reports directly to the SVP, Head of Clinical Development and plays a critical part in advancing Tango's precision oncology pipeline.

Responsibilities

• Drive pivotal phase III programs for TNG462 by leading protocol development, amendments, and operational execution, while partnering with the Head of Clinical Development on strategy and key decisions.
• Work cross-functionally with Clinical Operations, Regulatory, Medical Affairs, Biostatistics, and others; partner with Medical Affairs on publications, abstracts, and investigator meetings; represent Clinical Development in industry partnerships; and design and initiate study protocols and amendments in compliance with GCP/ICH and regulatory requirements.

Team Development & Management

• Directly manage clinical scientists supporting the PRMT5 program
• Provide mentorship and development opportunities for emerging clinical leaders
• Foster a culture of scientific rigor, operational excellence, and collaboration

Regulatory & Scientific Documentation

• Provide strategic input into regulatory meeting planning, preparation, and slide deck development
• Lead authorship and provide close oversight of regulatory documents including protocols, INDs, briefing documents, and responses to health authority questions
• Support the development and compilation of regulatory filings including INDs, CTAs, and NDAs

Operations & Governance

• Partner with Project Management on clinical governance meeting agendas and cross-functional alignment
• Establish and drive operational improvement initiatives
• Work closely with clinical teams to support patient recruitment strategies and maintain strong relationships with Principal Investigators
• Monitor adherence to protocols and ensure consistency in quality standards across all program activities

External Engagement & Scientific Leadership

• Build and maintain relationships with key investigators, thought leaders, and clinical trial sites
• Act as liaison between company and clinical investigators
• Represent PRMT5 clinical development at scientific conferences and investigator meetings
• Review/co-author medical publications emerging from clinical trial results

What You Bring

Required Qualifications

• MD degree with board certification or eligibility in medical oncology or hematology-oncology
• Minimum 15+ years of clinical development experience in oncology in the biotechnology or pharmaceutical industry, with at least 5 years in late-stage (Phase 2/3) programs
• Hands-on experience in the design, execution, and reporting of clinical trials in oncology, evaluating small molecule targeted agents and/or immunological therapies
• Direct experience with IND filings required
• Demonstrated experience leading global clinical programs from protocol design through regulatory submission
• Strong scientific writing skills with proven track record of regulatory document authorship
• Experience managing and mentoring clinical development teams
• Deep understanding of ICH-GCP, FDA regulations, and global regulatory requirements
• Effective leadership, people management, team-oriented and results-oriented style with strong interpersonal, verbal, written, communication, and presentation skills
• Flexible, creative, optimistic, and resourceful style and attitude

Preferred Qualifications

• Experience with targeted oncology therapies or precision medicine approaches
• Late-stage clinical development experience (Phase 3) and NDA/MAA filing and approval process
• Experience with novel mechanism agents
• Prior experience in biotech environment
• Experience working with pharmaceutical industry partnerships or collaborations
• Creative problem-solving approach with ability to identify and implement methods, techniques, procedures, and evaluation criteria to achieve results