Vice President, Clinical Development
Tango Therapeutics
August 13, 2026
Remote friendly (Boston, MA)
United States
Clinical Research and Development
Vice President, Clinical Development (Oncology)
Responsibilities:
- Provide strategic and scientific leadership for clinical development of vopimetostat; own and evolve the Clinical Development Plan
- Serve as Clinical Development leader on the Global Program Team; partner cross-functionally to shape program strategy and deliver milestones
- Lead design, execution, analysis, and interpretation of clinical studies (protocol development, dose optimization, indication expansion, data-driven decisions)
- Lead, mentor, and develop Medical Directors and Clinical Scientists
- Partner with Project Management, Clinical Operations, Regulatory Affairs, Clinical Pharmacology, Biometrics, Translational Medicine, Medical Writing, and Pharmacovigilance for high-quality execution
- Lead clinical contributions to regulatory interactions; oversee preparation/review of protocols, Investigator’s Brochures, INDs/CTAs, briefing packages, and marketing application components
- Interpret emerging clinical/safety/PK-PD/biomarker/competitive data to refine strategy
- Build relationships with key opinion leaders, investigators, and external collaborators
- Represent company at regulatory meetings, congresses, investigator meetings, and advisory boards
- Support scientific communications (publications, abstracts, presentations)
Qualifications/Requirements:
- MD with board certification (or eligibility) in Medical Oncology or related specialty
- 14+ years oncology drug development experience in biotech/pharma (early- and late-stage)
- Proven track record leading clinical development programs (CDPs, protocols, trials, regulatory interactions, NDA/BLA)
- Expertise designing/executing biomarker-driven oncology trials
- Experience leading/mentoring physicians and/or Clinical Scientists in matrixed organizations
- Deep understanding of oncology drug development, ICH-GCP, FDA, and global regulatory requirements
Skills:
- Strong scientific/clinical judgment; ability to integrate clinical, safety, pharmacology, biomarker, and competitive data
- Exceptional communication, collaboration, and cross-functional leadership; influence across teams
- Resourceful, adaptable, execution-oriented; passion for advancing therapies for patients with cancer
Salary Range:
- $332,800—$499,200 USD
Responsibilities:
- Provide strategic and scientific leadership for clinical development of vopimetostat; own and evolve the Clinical Development Plan
- Serve as Clinical Development leader on the Global Program Team; partner cross-functionally to shape program strategy and deliver milestones
- Lead design, execution, analysis, and interpretation of clinical studies (protocol development, dose optimization, indication expansion, data-driven decisions)
- Lead, mentor, and develop Medical Directors and Clinical Scientists
- Partner with Project Management, Clinical Operations, Regulatory Affairs, Clinical Pharmacology, Biometrics, Translational Medicine, Medical Writing, and Pharmacovigilance for high-quality execution
- Lead clinical contributions to regulatory interactions; oversee preparation/review of protocols, Investigator’s Brochures, INDs/CTAs, briefing packages, and marketing application components
- Interpret emerging clinical/safety/PK-PD/biomarker/competitive data to refine strategy
- Build relationships with key opinion leaders, investigators, and external collaborators
- Represent company at regulatory meetings, congresses, investigator meetings, and advisory boards
- Support scientific communications (publications, abstracts, presentations)
Qualifications/Requirements:
- MD with board certification (or eligibility) in Medical Oncology or related specialty
- 14+ years oncology drug development experience in biotech/pharma (early- and late-stage)
- Proven track record leading clinical development programs (CDPs, protocols, trials, regulatory interactions, NDA/BLA)
- Expertise designing/executing biomarker-driven oncology trials
- Experience leading/mentoring physicians and/or Clinical Scientists in matrixed organizations
- Deep understanding of oncology drug development, ICH-GCP, FDA, and global regulatory requirements
Skills:
- Strong scientific/clinical judgment; ability to integrate clinical, safety, pharmacology, biomarker, and competitive data
- Exceptional communication, collaboration, and cross-functional leadership; influence across teams
- Resourceful, adaptable, execution-oriented; passion for advancing therapies for patients with cancer
Salary Range:
- $332,800—$499,200 USD