Vice President, Chief U.S. Regulatory Counsel & Chief Compliance Officer

Why Sarepta? Why Now? The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne. We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients. What Sarepta Offers At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas: Physical and Emotional Wellness Financial Wellness Support for Caregivers For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us The Importance of the Role The Vice President, Chief U.S. Regulatory Counsel & Chief Compliance Officer is responsible for providing regulatory and commercialization legal support, advice, and counsel in connection with planning, tactics, and strategies in the U.S. undertaken primarily by the Regulatory and Commercial departments of the Company. This role also will be responsible for leading our global compliance program, as well as partnering closely with our Head of Legal International on ex-U.S. regulatory and commercialization activities The Opportunity to Make a Difference Regulatory & Compliance Leadership Serve as principal advisor to the Executive Team on compliance, regulatory, and commercialization risk, providing clear, pragmatic, risk‑based guidance aligned with corporate strategy and public‑company expectations. Lead the design, execution, and continuous evolution of Sarepta’s global compliance program, ensuring adherence to applicable federal, state, and international healthcare laws, regulations, and industry codes. Set and steward the Company’s legal and compliance strategy for ethical promotion, medical engagement, and patient advocacy, proactively reducing enforcement, investigation, and reputational risk. Provide executive oversight of Sales, Marketing, Commercial Operations, Medical Affairs, and Patient Advocacy activities, ensuring compliant execution across all commercial and medical engagement models. Serve as a senior decision‑maker on cross‑functional promotional, medical, and commercialization review committees, with accountability for legal and compliance risk assessment, escalation, and mitigation. Own monitoring, interpretation, and executive‑level communication of regulatory and enforcement developments impacting marketed pharmaceutical products, including FDA, OIG, DOJ, and related federal and state trends. Lead Compliance Committee governance and Board‑level reporting, delivering clear insight into enterprise risk, program effectiveness, and emerging regulatory exposure to support informed oversight. Provide executive‑level legal review and support negotiation of high‑risk and strategic commercial agreements, including consulting, speaker, advisory board, and key vendor arrangements. Lead Compliance Program to establish, maintain, and evolve Company policies, standards, and guardrails using a practical, risk‑based approach that supports business agility, scalability, and consistency while maintaining audit readiness and regulatory defensibility. Build, lead, and mentor a high‑performing compliance and regulatory legal organization, fostering accountability, professional development, and consistent application of legal and ethical standards. More about You Juris Doctor with 15-20 years of progressive legal experience, including senior in-house leadership within the biotechnology or pharmaceutical industry supporting marketed products. Deep expertise in the U.S. regulatory requirements applicable to a commercial-stage life sciences company, including with a focus in healthcare and FDA regulatory requirements. Proven executive presence with the ability to influence senior leaders and navigate high stakes, highly regulated business decisions. Strong judgment, integrity, and credibility as a visible leader responsible for enforcing Company policies and ethical standards. Demonstrated ability to balance legal risk with business priorities in a public company context. Highly organized, resilient leader capable of managing multiple priorities under pressure. Self-directed, collaborative, and committed to the highest professional standards. What Now? We’re always looking for solution-oriented, critical thinkers. So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply. #LI-Hybrid #LI-CM1 This position is hybrid, you will be expected to work on site at one of Sarepta’s facilities in the United States and/or attend Company-sponsored in-person events from time to time. The targeted salary range for this position is $313,200 - $391,500 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity. Candidates must be authorized to work in the U.S. Sarepta Therapeutics offers a competitive compensation and benefit package. Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify. Sarepta is on an urgent mission: engineer precision genetic medicine for rare diseases that devastate lives and cut futures short. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. Our deep pipeline is driven by our multi-platform technologies in siRNA, RNA and gene therapy. For more information, please visit www.sarepta.com or follow us on Twitter, LinkedIn, Instagram and Facebook.