TEMP - Scientist, In Vitro Pharmacology

Role Summary

We are seeking a highly motivated and collaborative Scientist to join our In Vitro Pharmacology team. This individual will be primarily responsible for developing, optimizing, and executing weekly in vitro pharmacology assays, as well as conducting molecular mechanism exploration and receptor occupancy studies in support of lead optimization campaigns in the context of multidisciplinary teams. The role will involve critical analysis of assay data to guide the identification and optimization of lead compounds, alongside thorough documentation and presentation of results.

Responsibilities

• Perform routine assays to support lead identification campaigns
• Develop, optimize, and conduct functional and binding assays to support profiling of molecules and mechanism of action studies
• Demonstrate clear understanding of assay mechanisms, workflow logistics and scientific background
• Assist with generating and maintaining cell lines and perform assays for their characterization
• Rapidly learn and implement new assays and analysis methods
• Track and document assay performance
• Assist with process improvements to enhance efficiency and research quality
• Effectively multitask and advance various projects simultaneously without compromising data quality or reproducibility
• Work independently as well as in a team environment toward timely execution of shared team deliverables

Qualifications

• BS/BA degree and 5+ years of relevant experience, including practical experience with a broad range of in vitro biological assays
• MS/MA degree in Molecular Pharmacology or related field and 2+ years of similar experience
• PhD in Molecular Pharmacology or related field with similar experience
• Collaborative and highly motivated
• Hands-on experience conducting in vitro assays for diverse pharmacological targets, such as SLC transporters, GPCRs, ion channels, and kinases
• Experience with radioligand binding assays preferred
• Expertise in molecular pharmacology and/or chemical biology preferred
• Experience and knowledge of mammalian cell culture and aseptic techniques
• Outstanding experimental design, problem-solving, and data analysis skills
• Ability to meet deadlines
• Experience using laboratory automation, inventory systems, data analysis (curve fitting, determination of potency, affinity, efficacy) and informatics systems
• Enthusiasm for developing and expanding technical and theoretical knowledge base
• Working knowledge of Excel, GraphPad Prism and Spotfire software helpful
• Working knowledge of LIMS systems preferred
• Excellent communication (written and verbal), time management, organizational and interpersonal skills to ensure operational excellence of daily laboratory needs
• Embody Neurocrine‚Äôs core values of Passion, Collaboration, Tenacity, Innovation, and Integrity