Stem Cell Principal Research Scientist, T1D Discovery Biology
Vertex Pharmaceuticals
4 days ago
On-site
Boston, MA
Clinical Research and Development
General Summary:
The Principal Scientist, Stem Cell Research provides scientific leadership and ownership of stem cell differentiation, characterization, and assay strategies supporting Vertex stem cell therapy programs. Hands-on, lab-based role defining experimental direction, setting scientific standards, and driving decision-making for complex stem cell-derived cellular platforms.
Key Duties And Responsibilities:
- Provide scientific leadership and ownership of stem cell-derived cellular models, differentiation platforms, and assay systems as a direct line manager and/or matrix manager of a small team.
- Define experimental strategy, technical roadmaps, and decision criteria for complex differentiation and characterization challenges.
- Distill multidimensional datasets into clear conclusions and actionable recommendations for program-level decisions.
- Lead development of robust, quantitative experimental platforms integrating stem cell biology, assay development, imaging, and computational analysis.
- Drive advanced troubleshooting and methods development for challenges in stem cell differentiation and functional assessment.
- Serve as a scientific point of accountability in cross-functional discussions; provide clear, data-driven guidance.
- Lead scientific outputs including invention disclosures, patent filings, publications, and internal technical documentation.
- Provide scientific mentorship and technical direction to junior scientists and research associates.
- Laboratory-based with regular on-site presence; occasional weekend work required.
Knowledge And Skills (Required/Preferred):
- Deep expertise in pluripotent stem cell culture and directed differentiation.
- Proficiency with functional, molecular, and imaging-based assays for differentiation and characterization.
- Ability to integrate experimental biology with quantitative data analysis.
- Strongly preferred: Python (or similar) for data analysis/visualization, workflow automation, or handling large datasets.
- Plus: high-throughput/automated cell culture and cell-based assays.
- Preferred: Benchling and ELN/LIMS systems.
- Excellent scientific communication.
Education And Experience:
- Ph.D. with 4–7 years relevant post-doctoral experience, or Master’s with 7+ years, or Bachelor’s with 10+ years (molecular/cell biology, developmental biology, stem cell biology, or related).
- Proven experience advancing stem cell-derived systems toward translational, preclinical, or product-enabling objectives.
- Ability to independently define scientific strategy, assess trade-offs, and provide data-driven recommendations.
- Experience mentoring/technical leadership/project coordination across multidisciplinary teams.
Pay Range (as stated): $147,200 - $220,800
The Principal Scientist, Stem Cell Research provides scientific leadership and ownership of stem cell differentiation, characterization, and assay strategies supporting Vertex stem cell therapy programs. Hands-on, lab-based role defining experimental direction, setting scientific standards, and driving decision-making for complex stem cell-derived cellular platforms.
Key Duties And Responsibilities:
- Provide scientific leadership and ownership of stem cell-derived cellular models, differentiation platforms, and assay systems as a direct line manager and/or matrix manager of a small team.
- Define experimental strategy, technical roadmaps, and decision criteria for complex differentiation and characterization challenges.
- Distill multidimensional datasets into clear conclusions and actionable recommendations for program-level decisions.
- Lead development of robust, quantitative experimental platforms integrating stem cell biology, assay development, imaging, and computational analysis.
- Drive advanced troubleshooting and methods development for challenges in stem cell differentiation and functional assessment.
- Serve as a scientific point of accountability in cross-functional discussions; provide clear, data-driven guidance.
- Lead scientific outputs including invention disclosures, patent filings, publications, and internal technical documentation.
- Provide scientific mentorship and technical direction to junior scientists and research associates.
- Laboratory-based with regular on-site presence; occasional weekend work required.
Knowledge And Skills (Required/Preferred):
- Deep expertise in pluripotent stem cell culture and directed differentiation.
- Proficiency with functional, molecular, and imaging-based assays for differentiation and characterization.
- Ability to integrate experimental biology with quantitative data analysis.
- Strongly preferred: Python (or similar) for data analysis/visualization, workflow automation, or handling large datasets.
- Plus: high-throughput/automated cell culture and cell-based assays.
- Preferred: Benchling and ELN/LIMS systems.
- Excellent scientific communication.
Education And Experience:
- Ph.D. with 4–7 years relevant post-doctoral experience, or Master’s with 7+ years, or Bachelor’s with 10+ years (molecular/cell biology, developmental biology, stem cell biology, or related).
- Proven experience advancing stem cell-derived systems toward translational, preclinical, or product-enabling objectives.
- Ability to independently define scientific strategy, assess trade-offs, and provide data-driven recommendations.
- Experience mentoring/technical leadership/project coordination across multidisciplinary teams.
Pay Range (as stated): $147,200 - $220,800