Statistical Science Director

Job Title: Statistical Science Director GCL: F Introduction to role: Are you ready to lead statistical strategy that shapes pivotal decisions across global medicine development? As Statistical Science Director at AstraZeneca, you will turn sophisticated evidence into clear direction, guiding programs from early discovery through registration and beyond. Your work will directly influence how quickly and confidently we bring entrepreneurial therapies to patients. Do you thrive on turning uncertainty into actionable insight? In this high-visibility role, you will be a key voice at decision forums, set standards for study design and quantitative difficulty, and mentor a dedicated team. You will collaborate across therapy areas and teams, applying biometrics expertise in new ways to enhance impact on patient outcomes and business value. Accountabilities: Statistical Design Leadership: Lead statistical design and strategy across product development plans, preclinical studies, regulatory pathways, health technology assessment and commercial activities aligned to the product’s stage. Study Excellence and Delivery: Own statistical content for study designs, protocols, analysis plans, interpretation and submissions, ensuring transparency, difficulty and timely delivery. Benefit–Risk and Uncertainty: Quantify benefit, risk, value and uncertainty of emerging product profiles and communicate insights that drive confident decisions. Global Leadership and Team Direction: Provide leadership and direction to internal and external statisticians; mentor, coach and support technical education and training for the Statistics community. External Partnerships and Representation: Partner with CROs to meet quality and timelines; represent AstraZeneca with health authorities, advisory boards, conferences, workshops and payer interactions. Methodology Innovation: Maintain deep knowledge of statistical methodology; promote, investigate and implement novel approaches (e.g., adaptive designs, Bayesian methods) that strengthen decision-making. Strategic Governance Influence: Represent statistical strategy and decision-making at internal governance, including review boards, therapy area leadership teams and ESPC/LSPC, shaping progression and investment decisions. Project Leadership or Methodological Advancement: Lead projects end-to-end and/or drive statistical methodological advances that elevate enterprise-wide standards. Essential Skills/Experience: Min 12+ years of experience as a Statistician in pharma/healthcare industry Up to date and implements novel stats approaches Experience with and broad awareness of regulatory interactions and/or submissions Ability to provide Input to Clinical Development Plan & Exemplary technical skills such as Clinical Trial Protocol, Regulatory Interaction, Data-driven analysis, Decision Making in drug development, Sophisticated Statistical Computation & Methodology Excellent communication skills/ builds strong relationships Track record of expert Leadership role or nationally recognized externally as a statistical technical expert Desirable Skills/Experience: PhD or equivalent in Statistics, Biostatistics, or a related quantitative field Proven impact across multiple therapy areas, including experience with health technology assessment and payer evidence Expertise in advanced trial designs and decision analysis (adaptive, Bayesian, platform/master protocols) Proficiency in R and/or SAS and modern reproducible analysis practices; familiarity with version control and scalable computing Track record of leading cross-functional teams and partnerships with CROs to deliver to quality and time Experience influencing internal governance bodies and external collaborators, including health authorities Ability to translate complex quantitative evidence into clear recommendations for senior leaders When we put unexpected teams in the same room, we fuel bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. Why AstraZeneca: Join a company where bold, curious minds work side by side to solve hard problems and move quickly from insight to impact. You will influence high-visibility decisions, apply ground breaking methods to real-world data, and see your work translate into medicines that make a tangible difference for patients across the globe. We bring diverse teams together to spark new thinking, value kindness alongside ambition, and provide the support, challenge and recognition needed to grow while creating outcomes that matter. Step into a high-exposure director role where your statistics shape real-world outcomes—send your application today and start making decisive impact! Date Posted 07-Apr-2026 Closing Date 09-Apr-2026 AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.