Staff Mechanical Engineer
10x Genomics
August 24, 2026
Full-time
Remote friendly (Pleasanton, CA)
Worldwide
Other
Role: Senior Mechanical Engineer leading development of mechanical systems for genomics instruments at 10x Genomics. Responsibilities include designing large-scale biotechnological hardware, integrating multidisciplinary subsystems (fluidics, optics, electrical), and driving innovation in spatial biology applications. The role encompasses project ownership from concept through manufacturing, ensuring compliance with regulatory standards, optimizing designs for manufacturability, and leading process improvements. Collaboration involves cross-functional teams in Chemistry, Molecular Biology, Software, and Electrical Engineering, with responsibilities for technical leadership, stakeholder communication, and mentoring. Qualifications: BS/MS/Ph.D. in Mechanical Engineering with at least 10 years in biotech, medical devices, or high-tech instrumentation; expertise in CAD (SolidWorks preferred), FEA, CFD, and electromechanical system integration; thorough understanding of product lifecycle stages and design control processes. Preferred skills include excellent communication, experience in control systems, dynamics, or fluidics, and hands-on prototyping capabilities. The position requires leadership in innovation, patent development, and team mentorship. High-value specifics include focus on genomics instrumentation, biotech innovation, and cross-disciplinary system integration. Work setup: not specified.