Sr. Scientist - T-Cell Therapy Immunology
Regeneron
6 months ago
On-site
Cambridge, MA
Clinical Research and Development
Responsibilities:
- Characterize CAR/TCR-T cell therapies and support cell therapy discovery and pre-clinical research.
- Independently design and execute studies to enable data-driven decisions (e.g., selecting top CAR/TCR-T constructs based on in vitro characterization).
- Perform standard T cell characterization assays, including co-cultures to evaluate antigen-dependent cytokine release, target cell cytotoxicity, and T cell proliferation.
- Assess and implement new cell therapy technologies tailored to CAR T programs; develop novel CAR designs.
- Represent the Research team in cross-functional forums and present/analyze data at working groups, seminars, and leadership meetings.
- Maintain detailed and timely records of experimental protocols, results, and observations.
Qualifications:
- PhD in immunology, molecular biology, or a related discipline with 0–3 years industry experience; or MS and/or BS with 8–10+ years industry experience.
- Strong background in immunology, cell biology, and molecular biology.
- Expertise in development of novel CAR/TCR-T cell therapies for oncology indications.
- Experience/knowledge of T cell immunology, immuno-oncology, cell therapy, mammalian cell culture, and primary human cell workflows.
- Experience supporting CAR/TCR-T therapy programs from discovery to early development (plus).
- Expertise in standard immunological assays (flow cytometry, ELISA, MSD/Luminex, cytotoxicity assays, T cell functional assays).
- Expertise in molecular biology techniques (cloning, cell line engineering) and gene editing (CRISPR/Cas9) (required).
- Experience with FlowJo and Graphpad Prism and Geneious (plus).
Application instructions:
- Apply now.
- Characterize CAR/TCR-T cell therapies and support cell therapy discovery and pre-clinical research.
- Independently design and execute studies to enable data-driven decisions (e.g., selecting top CAR/TCR-T constructs based on in vitro characterization).
- Perform standard T cell characterization assays, including co-cultures to evaluate antigen-dependent cytokine release, target cell cytotoxicity, and T cell proliferation.
- Assess and implement new cell therapy technologies tailored to CAR T programs; develop novel CAR designs.
- Represent the Research team in cross-functional forums and present/analyze data at working groups, seminars, and leadership meetings.
- Maintain detailed and timely records of experimental protocols, results, and observations.
Qualifications:
- PhD in immunology, molecular biology, or a related discipline with 0–3 years industry experience; or MS and/or BS with 8–10+ years industry experience.
- Strong background in immunology, cell biology, and molecular biology.
- Expertise in development of novel CAR/TCR-T cell therapies for oncology indications.
- Experience/knowledge of T cell immunology, immuno-oncology, cell therapy, mammalian cell culture, and primary human cell workflows.
- Experience supporting CAR/TCR-T therapy programs from discovery to early development (plus).
- Expertise in standard immunological assays (flow cytometry, ELISA, MSD/Luminex, cytotoxicity assays, T cell functional assays).
- Expertise in molecular biology techniques (cloning, cell line engineering) and gene editing (CRISPR/Cas9) (required).
- Experience with FlowJo and Graphpad Prism and Geneious (plus).
Application instructions:
- Apply now.