Sr. Scientist, Protein Biochemistry

Role Summary

Sr. Scientist to join the Protein Biochemistry group. Responsible for performing biochemical and biophysical assays to characterize protein biologics and gene therapy candidates to support late-stage development and commercialization efforts.

Responsibilities

• Conduct biochemical and biophysical characterization experiments on therapeutic protein and gene therapy candidates (AAV/pseudovirus) for late-stage development and regulatory submissions.
• Provide input on experimental design and suggest modifications in protocols or experimental methods to meet program needs.
• Advance method development to enrich and characterize size/charge variants of therapeutic protein and gene therapy drug candidates.
• Document experiments, results and findings in electronic laboratory notebook; present work at group and department meetings; contribute to drafting protocols, method development reports, regulatory submission sections, and peer-reviewed articles.
• Maintain instruments, troubleshoot problems, and order/maintain supplies.

Qualifications

• PhD with 0-3 years, MS with 8-10 years, or BS with 13+ years of proven experience.
• In-depth knowledge of protein structure and function.
• Experience developing new analytical methods and optimizing existing methods (preferred).
• Experience with H/UPLC, A4F/SEC-multi-angle-light scattering, capillary electrophoresis, and protein purification (preferred).
• Prior experience with AAV, pseudovirus and LNP (plus).

Skills

• Analytical method development
• Biochemical and biophysical characterization
• Instrument maintenance and troubleshooting
• Data documentation and communication

Education

• PhD, MS, or BS as specified in qualifications

Additional Requirements

• On-site work may be required depending on location