Sr Scientist/Principal Scientist - Genomics Sciences
Eli Lilly and Company
June 28, 2026
On-site
Boston, MA
Clinical Research and Development
Key Responsibilities:
- Execute and optimize NGS library preparation workflows (e.g., 3’ RNA-seq, mRNA-seq) across targeted and large-scale screening campaigns, maintaining high quality and throughput
- Track, document, and QC samples through all stages of assay development
- Develop, troubleshoot, and refine genomics assay protocols to meet evolving program needs (new library chemistries, multiplexing strategies, sample input optimization)
- Maintain sample tracking, chain-of-custody documentation, and electronic lab notebook records in compliance with Lilly quality standards
- Collaborate with computational genomics, medicinal chemistry, and biology teams to generate robust, interpretable, decisional data
- Participate in cross-functional teams to contribute to assay design, data interpretation, and experimental prioritization
- Support lab infrastructure (reagent inventory, equipment maintenance, and continuous improvement of SOPs)
Basic Qualifications:
- Bachelor’s degree in genomics, molecular biology, biochemistry, genetics, or related field with 3+ years relevant lab experience; OR Master’s degree with 1+ years relevant lab experience
- Authorized to work in the United States full-time; Lilly will not sponsor work authorization or visas
Preferred Qualifications:
- Hands-on NGS library preparation, QC (Qubit, TapeStation/Bioanalyzer, qPCR quantification), and sequencer operation
- Strong sample management, documentation, and reproducibility
- Experience with high-throughput/pooled screening
- Single-cell genomics or spatial transcriptomics; RNA therapeutics biology (siRNA, ASO)
- Bioinformatics (command line, R/Python, NGS analysis: alignment/QC/differential expression)
- Automation platforms (Hamilton, Beckman); method development/assay optimization
- Experience using/developing ELN-based documentation tools
Benefits:
- Company-sponsored 401(k), pension, vacation; medical/dental/vision/prescription benefits; flexible benefits (e.g., healthcare/dependent day care); life insurance/death benefits; time off/leave of absence; well-being benefits (e.g., employee assistance, fitness, clubs)
Application Instructions:
- If you require accommodation to submit a resume, complete the workplace accommodation request form: https://careers.lilly.com/us/en/workplace-accommodation
- Execute and optimize NGS library preparation workflows (e.g., 3’ RNA-seq, mRNA-seq) across targeted and large-scale screening campaigns, maintaining high quality and throughput
- Track, document, and QC samples through all stages of assay development
- Develop, troubleshoot, and refine genomics assay protocols to meet evolving program needs (new library chemistries, multiplexing strategies, sample input optimization)
- Maintain sample tracking, chain-of-custody documentation, and electronic lab notebook records in compliance with Lilly quality standards
- Collaborate with computational genomics, medicinal chemistry, and biology teams to generate robust, interpretable, decisional data
- Participate in cross-functional teams to contribute to assay design, data interpretation, and experimental prioritization
- Support lab infrastructure (reagent inventory, equipment maintenance, and continuous improvement of SOPs)
Basic Qualifications:
- Bachelor’s degree in genomics, molecular biology, biochemistry, genetics, or related field with 3+ years relevant lab experience; OR Master’s degree with 1+ years relevant lab experience
- Authorized to work in the United States full-time; Lilly will not sponsor work authorization or visas
Preferred Qualifications:
- Hands-on NGS library preparation, QC (Qubit, TapeStation/Bioanalyzer, qPCR quantification), and sequencer operation
- Strong sample management, documentation, and reproducibility
- Experience with high-throughput/pooled screening
- Single-cell genomics or spatial transcriptomics; RNA therapeutics biology (siRNA, ASO)
- Bioinformatics (command line, R/Python, NGS analysis: alignment/QC/differential expression)
- Automation platforms (Hamilton, Beckman); method development/assay optimization
- Experience using/developing ELN-based documentation tools
Benefits:
- Company-sponsored 401(k), pension, vacation; medical/dental/vision/prescription benefits; flexible benefits (e.g., healthcare/dependent day care); life insurance/death benefits; time off/leave of absence; well-being benefits (e.g., employee assistance, fitness, clubs)
Application Instructions:
- If you require accommodation to submit a resume, complete the workplace accommodation request form: https://careers.lilly.com/us/en/workplace-accommodation