Sr. Scientist, Peptide & Oligonucleotide API Development

Who We Are: At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs. What We Do: Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X and Facebook. (*in collaboration with AbbVie) About the Role: We are seeking a highly motivated Scientist to join our API Development group within CMC. In this critical role, you will operate at the interface of synthetic chemistry and chemical biology, applying your expertise in chemical synthesis and conjugation to create innovative strategies and execution of process development and optimization for novel hybrid therapeutics and emerging modalities. The successful candidate will contribute to the development of peptide and oligonucleotide synthetic processes, as well as complexation to large-molecule therapeutics, including antibody/Fc-peptide and oligonucleotide conjugates across multiple therapeutic areas. You will lead and support the development, scale-up, and management of manufacturing and purification processes while working closely with internal CMC and cross-functional teams and external CDMOs to ensure high-quality process innovation and timely API delivery. This role also includes project management responsibilities within CMC and Chemical Development programs, with opportunities to lead workstreams or projects. Your expertise in peptide and oligonucleotide process development will play a key role in advancing Neurocrine’s pipeline. _ Your Contributions (include, but are not limited to): Design and execute laboratory experiments to optimize and characterize peptide and oligonucleotide chemistries, including solid-phase, liquid-phase, and hybrid synthesis approaches Develop and optimize bioconjugation processes and downstream purification strategies for peptide and oligonucleotide-based therapeutics Advance synthetic processes using novel chemistry and emerging technologies Manage external CDMOs supporting process development and GLP/GMP manufacturing of development candidates Clearly communicate scientific rationale, results, and interpretations in project, team, and departmental settings, contributing to strategic decision-making Support regulatory submissions for development candidates Collaborate cross-functionally to ensure successful technology transfer from laboratory to manufacturing Other duties assigned as required Requirements: PhD in Chemistry with relevant industry or postdoctoral experience OR MS in Chemistry with 3+ years of relevant pharmaceutical/process development experience OR BS/BA in Chemistry with 5+ years of relevant experience, including API manufacturing Proven experience in process development, optimization, and scale-up of peptide and/or oligonucleotide synthesis from milligram/gram scale to multi-kilogram scale Strong expertise in purification strategies, including reverse-phase, ion-exchange, and/or affinity chromatography Experience in peptide/oligonucleotide CMC development and GMP manufacturing preferred Hands-on experience in bioconjugation chemistry and downstream purification, including generation and characterization of conjugates Solid understanding of cGMP requirements for drug substance development Ability to serve as a technical liaison across discovery, preclinical, quality, regulatory, and supply chain teams Strong laboratory skills and experience with a wide range of scientific equipment and tools Excellent analytical, organizational, communication, and presentation skills Demonstrated ability to manage multiple priorities and meet deadlines with accuracy and efficiency Proven ability to collaborate effectively within cross-functional teams #LI-LS1 Neurocrine Biosciences is an EEO/Disability/Vets employer. We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description. _ The annual base salary we reasonably expect to pay is $110,800.00-$151,000.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans. We are a top place to work. Neurocrine Biosciences was named one of the FORTUNE Best Workplaces in Biopharma™ 2025. We were also named a Great Place to Work® Certified company. ©2025 Fortune Media IP Limited. All rights reserved. Used under license. OUR VALUES: PASSION: We are driven and love what we do. We are committed to our goals and to making a difference. INTEGRITY: We do the right thing for patients and our community. We take accountability. We speak up. COLLABORATION: We trust one another. We are inclusive. We are respectful. We are transparent. Together we succeed. INNOVATION: We seek and create optimal solutions. TENACITY: We do not quit. We adapt. We accomplish what others cannot. Come join our team during this exciting time of growth and opportunities!