Sr. Scientist, Peptide & Oligonucleotide API Development
Neurocrine Biosciences
2 months ago
On-site
San Diego, CA
Operations
About the Role
- Operate at the interface of synthetic chemistry and chemical biology to execute process development and optimization for novel hybrid therapeutics and emerging modalities.
- Contribute to the development of peptide and oligonucleotide synthetic processes and to complexation with large-molecule therapeutics (e.g., antibody/Fc-peptide and oligonucleotide conjugates).
- Lead and support development, scale-up, and management of manufacturing and purification processes.
- Collaborate with internal CMC and cross-functional teams and manage external CDMOs to ensure high-quality process innovation and timely API delivery.
- Include project management responsibilities within CMC and Chemical Development programs, with opportunities to lead workstreams/projects.
Your Contributions (include, But Are Not Limited To)
- Design and execute experiments to optimize and characterize peptide and oligonucleotide chemistries (solid-phase, liquid-phase, and hybrid synthesis).
- Develop/optimize bioconjugation processes and downstream purification strategies.
- Advance synthetic processes using novel chemistry and emerging technologies.
- Manage external CDMOs supporting process development and GLP/GMP manufacturing.
- Communicate scientific rationale, results, and interpretations to support strategic decisions.
- Support regulatory submissions for development candidates.
- Collaborate cross-functionally to ensure technology transfer from lab to manufacturing.
Requirements
- PhD in Chemistry with relevant industry or postdoctoral experience OR MS in Chemistry with 3+ years relevant pharmaceutical/process development experience OR BS/BA in Chemistry with 5+ years relevant experience including API manufacturing.
- Proven experience developing, optimizing, and scaling peptide and/or oligonucleotide synthesis from milligram/gram to multi-kilogram scale.
- Strong purification expertise (reverse-phase, ion-exchange, and/or affinity chromatography).
- Experience in peptide/oligonucleotide CMC development and GMP manufacturing (preferred).
- Hands-on experience in bioconjugation chemistry and downstream purification; generation/characterization of conjugates.
- Solid understanding of cGMP requirements for drug substance development.
- Ability to act as technical liaison across discovery, preclinical, quality, regulatory, and supply chain.
- Strong laboratory skills; excellent analytical, organizational, communication, and presentation skills.
- Ability to manage multiple priorities and meet deadlines.
- Proven ability to collaborate effectively in cross-functional teams.
Benefits
- Base salary: $110,800.00–$151,000.00 (annual).
- Annual bonus with target of 20% of earned base salary; eligibility for equity-based long-term incentive.
- Retirement savings plan (with company match), paid vacation/holidays/personal days, paid caregiver/parental and medical leave, and health benefits (medical, prescription drug, dental, vision).
- Operate at the interface of synthetic chemistry and chemical biology to execute process development and optimization for novel hybrid therapeutics and emerging modalities.
- Contribute to the development of peptide and oligonucleotide synthetic processes and to complexation with large-molecule therapeutics (e.g., antibody/Fc-peptide and oligonucleotide conjugates).
- Lead and support development, scale-up, and management of manufacturing and purification processes.
- Collaborate with internal CMC and cross-functional teams and manage external CDMOs to ensure high-quality process innovation and timely API delivery.
- Include project management responsibilities within CMC and Chemical Development programs, with opportunities to lead workstreams/projects.
Your Contributions (include, But Are Not Limited To)
- Design and execute experiments to optimize and characterize peptide and oligonucleotide chemistries (solid-phase, liquid-phase, and hybrid synthesis).
- Develop/optimize bioconjugation processes and downstream purification strategies.
- Advance synthetic processes using novel chemistry and emerging technologies.
- Manage external CDMOs supporting process development and GLP/GMP manufacturing.
- Communicate scientific rationale, results, and interpretations to support strategic decisions.
- Support regulatory submissions for development candidates.
- Collaborate cross-functionally to ensure technology transfer from lab to manufacturing.
Requirements
- PhD in Chemistry with relevant industry or postdoctoral experience OR MS in Chemistry with 3+ years relevant pharmaceutical/process development experience OR BS/BA in Chemistry with 5+ years relevant experience including API manufacturing.
- Proven experience developing, optimizing, and scaling peptide and/or oligonucleotide synthesis from milligram/gram to multi-kilogram scale.
- Strong purification expertise (reverse-phase, ion-exchange, and/or affinity chromatography).
- Experience in peptide/oligonucleotide CMC development and GMP manufacturing (preferred).
- Hands-on experience in bioconjugation chemistry and downstream purification; generation/characterization of conjugates.
- Solid understanding of cGMP requirements for drug substance development.
- Ability to act as technical liaison across discovery, preclinical, quality, regulatory, and supply chain.
- Strong laboratory skills; excellent analytical, organizational, communication, and presentation skills.
- Ability to manage multiple priorities and meet deadlines.
- Proven ability to collaborate effectively in cross-functional teams.
Benefits
- Base salary: $110,800.00–$151,000.00 (annual).
- Annual bonus with target of 20% of earned base salary; eligibility for equity-based long-term incentive.
- Retirement savings plan (with company match), paid vacation/holidays/personal days, paid caregiver/parental and medical leave, and health benefits (medical, prescription drug, dental, vision).