Sr. Scientist I /II - Pharmacology
Novartis
13 days ago
On-site
Cambridge, MA
Clinical Research and Development
Key responsibilities:
- Execute preclinical in vivo studies, including dosing, tumor implantation, monitoring, and tissue and blood collection, following standard operating procedures.
- Develop and apply in vivo oncology models to assess antitumor activity, biomarkers, and pharmacokinetic and pharmacodynamic relationships.
- Design, optimize, troubleshoot, and analyze multicolor flow cytometry panels to characterize tumor and peripheral immune responses.
- Perform ex vivo and in vitro workflows, including cell culture, tumor cell preparation, and tissue processing into single-cell suspensions.
- Generate and interpret high-quality datasets using flow cytometry analysis software and GraphPad Prism for visualization and summaries.
- Maintain accurate experimental documentation in an electronic laboratory notebook; contribute to study reports and presentations.
- Collaborate across functions to communicate findings, support study planning, and advance oncology discovery priorities.
Essential requirements:
- Bachelor’s or Master’s degree in Immunology, Biology, or a related field with relevant laboratory experience.
- Hands-on mouse in vivo experience (dosing, tumor implantation, monitoring, tissue collection).
- Oncology in vivo model experience (xenograft or syngeneic systems).
- Strong multicolor flow cytometry expertise (panel design, optimization, troubleshooting, data analysis).
- Flow cytometry analysis software experience (e.g., FlowJo).
- Ability to execute experiments independently and produce high-quality, reproducible data.
- Strong data interpretation and ability to present results in a multidisciplinary setting.
- Strong attention to detail, organization, and collaborative, proactive work style.
Desirable requirements:
- Experience establishing cell line-derived xenograft, patient-derived xenograft, or syngeneic tumor models.
- Experience with immune profiling of tumors and secondary lymphoid organs using multicolor flow cytometry.
- Execute preclinical in vivo studies, including dosing, tumor implantation, monitoring, and tissue and blood collection, following standard operating procedures.
- Develop and apply in vivo oncology models to assess antitumor activity, biomarkers, and pharmacokinetic and pharmacodynamic relationships.
- Design, optimize, troubleshoot, and analyze multicolor flow cytometry panels to characterize tumor and peripheral immune responses.
- Perform ex vivo and in vitro workflows, including cell culture, tumor cell preparation, and tissue processing into single-cell suspensions.
- Generate and interpret high-quality datasets using flow cytometry analysis software and GraphPad Prism for visualization and summaries.
- Maintain accurate experimental documentation in an electronic laboratory notebook; contribute to study reports and presentations.
- Collaborate across functions to communicate findings, support study planning, and advance oncology discovery priorities.
Essential requirements:
- Bachelor’s or Master’s degree in Immunology, Biology, or a related field with relevant laboratory experience.
- Hands-on mouse in vivo experience (dosing, tumor implantation, monitoring, tissue collection).
- Oncology in vivo model experience (xenograft or syngeneic systems).
- Strong multicolor flow cytometry expertise (panel design, optimization, troubleshooting, data analysis).
- Flow cytometry analysis software experience (e.g., FlowJo).
- Ability to execute experiments independently and produce high-quality, reproducible data.
- Strong data interpretation and ability to present results in a multidisciplinary setting.
- Strong attention to detail, organization, and collaborative, proactive work style.
Desirable requirements:
- Experience establishing cell line-derived xenograft, patient-derived xenograft, or syngeneic tumor models.
- Experience with immune profiling of tumors and secondary lymphoid organs using multicolor flow cytometry.