Sr Scientist, Genomic Sciences and Target Discovery
Alkermes
August 24, 2026
On-site
Greater Boston
Clinical Research and Development
Key Responsibilities
- Design, develop, and execute CRISPR-based functional genomics strategies to validate therapeutic hypotheses in vitro and in preclinical models of CNS diseases.
- Use CRISPR/Cas9, CRISPRa, and CRISPRi to modulate gene expression and study target biology in neuroanatomy and neurocircuitry contexts.
- Develop and optimize CRISPR delivery methods (viral and non-viral) for precise CNS gene editing.
- Establish and validate CRISPR-edited rodent models using molecular, cellular, and behavioral readouts to assess target engagement and functional outcomes.
- Collaborate cross-functionally with neuroscience, pharmacology, and translational teams to integrate functional genomics insights into drug discovery.
- Perform molecular and cellular assays (PCR, NGS, immunohistochemistry, single-cell sequencing) to confirm CRISPR-mediated gene modifications.
- Maintain detailed experimental and data interpretation records per corporate documentation standards.
- Stay current on emerging CRISPR technologies and functional genomics to drive innovation.
- Communicate findings and recommendations to internal and external stakeholders.
Required Qualifications
- Ph.D. in Neuroscience, Molecular Biology, Genomics, or related field; 3+ years functional genomics experience (industry CNS drug discovery preferred).
- Proficiency in human (Mendelian/population genetics) and model organism genetics.
- Expertise in CRISPR/Cas9, CRISPRa, and CRISPRi.
- In vivo CNS CRISPR delivery experience (e.g., AAV, lipid nanoparticles, electroporation).
- Strong neuroanatomy/neurocircuitry background; experience validating gene edits in preclinical models.
- Proficiency in molecular biology and tissue culture; develop/maintain CRISPR-edited cell lines.
- Familiarity with rodent models, behavioral assays, and CNS-relevant phenotyping.
- Strong data analysis/interpretation; bioinformatics experience.
- Excellent communication and cross-disciplinary collaboration.
Preferred Qualifications
- Experience with single-cell RNA-seq, spatial transcriptomics, or electrophysiology.
- Proficiency with Python, R, or Unix CLI for CRISPR screening data.
Compensation & Work Setting
- Base salary: $151,000–$170,000; eligible for annual performance bonus; competitive benefits package.
- Onsite 5 days/week.
- Design, develop, and execute CRISPR-based functional genomics strategies to validate therapeutic hypotheses in vitro and in preclinical models of CNS diseases.
- Use CRISPR/Cas9, CRISPRa, and CRISPRi to modulate gene expression and study target biology in neuroanatomy and neurocircuitry contexts.
- Develop and optimize CRISPR delivery methods (viral and non-viral) for precise CNS gene editing.
- Establish and validate CRISPR-edited rodent models using molecular, cellular, and behavioral readouts to assess target engagement and functional outcomes.
- Collaborate cross-functionally with neuroscience, pharmacology, and translational teams to integrate functional genomics insights into drug discovery.
- Perform molecular and cellular assays (PCR, NGS, immunohistochemistry, single-cell sequencing) to confirm CRISPR-mediated gene modifications.
- Maintain detailed experimental and data interpretation records per corporate documentation standards.
- Stay current on emerging CRISPR technologies and functional genomics to drive innovation.
- Communicate findings and recommendations to internal and external stakeholders.
Required Qualifications
- Ph.D. in Neuroscience, Molecular Biology, Genomics, or related field; 3+ years functional genomics experience (industry CNS drug discovery preferred).
- Proficiency in human (Mendelian/population genetics) and model organism genetics.
- Expertise in CRISPR/Cas9, CRISPRa, and CRISPRi.
- In vivo CNS CRISPR delivery experience (e.g., AAV, lipid nanoparticles, electroporation).
- Strong neuroanatomy/neurocircuitry background; experience validating gene edits in preclinical models.
- Proficiency in molecular biology and tissue culture; develop/maintain CRISPR-edited cell lines.
- Familiarity with rodent models, behavioral assays, and CNS-relevant phenotyping.
- Strong data analysis/interpretation; bioinformatics experience.
- Excellent communication and cross-disciplinary collaboration.
Preferred Qualifications
- Experience with single-cell RNA-seq, spatial transcriptomics, or electrophysiology.
- Proficiency with Python, R, or Unix CLI for CRISPR screening data.
Compensation & Work Setting
- Base salary: $151,000–$170,000; eligible for annual performance bonus; competitive benefits package.
- Onsite 5 days/week.