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Sr. Scientist - Cardiometabolic Research

Amgen
Full-time
Remote friendly (South San Francisco, CA)
United States
Clinical Research and Development

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Role Summary

Sr. Scientist - Cardiometabolic Research

Responsibilities

  • Design and perform laboratory-based assays to deepen our understanding of cardiometabolic disease biology
  • Develop functional screening assays and evaluate potential therapeutics to advance the pre-clinical pipeline
  • Organize and interpret data and present work to colleagues and project teams
  • Contribute to the identification and validation of therapeutic targets
  • Coordinate cross-functional efforts to achieve project goals and drive project advancement

Qualifications

  • Basic Qualifications:
    • Doctorate Degree (PhD) or
    • Master’s Degree with 3 years of experience or
    • Bachelor’s Degree with 5 years of experience
  • Preferred Qualifications:
    • Demonstrated expertise in the molecular mechanisms underlying cardiovascular disease biology. The successful candidate will have a strong record of high-impact publications in this field.
    • Extensive experience in high-throughput cell-based and biochemical assays, including live cell imaging and image processing, qPCR, ddPCR, Western Blot, MSD, ELISA and flow-based expression analysis
    • Hands-on expertise with cell line engineering technologies, including CRISPR and lentivirus, retrovirus-, or piggyBac-based stable cell line generation
    • Experience with high-throughput functional perturbation approaches, including CRISPR-based or RNAi screens
    • Experience with single-cell transcriptomics or other omics data for disease pathology and novel target identification

Skills

  • Excellent communication skills
  • Strong collaboration and ability to work with cross-functional teams
  • Analytical and data interpretation abilities

Education

  • Doctorate Degree (PhD) or Master’s/Bachelor’s with applicable experience as described above

Additional Requirements

  • Travel: Not specified as essential
  • Physical demands: Not specified as essential