Sr Scientist - Analytical and Biological Mass Spectrometry (ABMS)
Regeneron
8 hours ago
On-site
Tarrytown, NY
Clinical Research and Development
A Typical Day In This Role Looks Like
- Lead and deliver on characterization activities to elucidate product quality attributes like post-translational modifications, sequence variants, charge variants, size variants, and host cell proteins.
- Provide technical support for cross-functional teams (formulation development, upstream/downstream process development, manufacturing) to tackle real-time development challenges in process development and manufacturing for OOS/OOT investigations.
- Proactively advance LC-MS analysis of biotherapeutics by developing technical innovations that support future developmental needs and/or efficiency gains.
- Perform sample preparation and LC-MS-based experiments independently based on SOPs; document experiments, results, and findings in an electronic laboratory notebook (ELN).
- Prepare and review regulatory submission documents (IND, comparability, BLA) and manuscripts for peer-reviewed publication.
- Serve as a team representative, provide analytical expertise to cross-functional teams, and present findings at internal and external meetings.
This Role May Be For You If
- You thrive in a fast-paced, collaborative environment and deliver results with efficiency and ownership.
- You quickly learn new technologies, tackle complex problems, and have a passion for science.
- You are self-motivated and proactive, prioritize effectively, and drive work forward with minimal supervision.
Qualifications
- BS (10+ years), MS (7+ years), or PhD (0–3+ years) in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a closely related field.
- Extensive experience with advanced mass spectrometers (Orbitrap, Q-TOF, Triple Quadrupole, etc.), liquid chromatography, and data processing software (Proteome Discoverer, Skyline, Protein Metrics, etc.) (desired).
- Knowledge/experience with extended monoclonal antibody characterization by mass spectrometry to support cell line and upstream/downstream development (plus).
- Experience with automated liquid-handling systems (e.g., Bravo, KingFisher) and with experimental design/data analysis (e.g., DOE, molecular modeling, graphing, statistical tools such as JMP) (plus).
Benefits
- U.S. benefits may include medical, dental, vision, life and disability insurance, fitness centers, 401(k) match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves.
- Salary range (annually): $109,900.00 - $179,300.00.
Application Instructions
- Apply now.
- Lead and deliver on characterization activities to elucidate product quality attributes like post-translational modifications, sequence variants, charge variants, size variants, and host cell proteins.
- Provide technical support for cross-functional teams (formulation development, upstream/downstream process development, manufacturing) to tackle real-time development challenges in process development and manufacturing for OOS/OOT investigations.
- Proactively advance LC-MS analysis of biotherapeutics by developing technical innovations that support future developmental needs and/or efficiency gains.
- Perform sample preparation and LC-MS-based experiments independently based on SOPs; document experiments, results, and findings in an electronic laboratory notebook (ELN).
- Prepare and review regulatory submission documents (IND, comparability, BLA) and manuscripts for peer-reviewed publication.
- Serve as a team representative, provide analytical expertise to cross-functional teams, and present findings at internal and external meetings.
This Role May Be For You If
- You thrive in a fast-paced, collaborative environment and deliver results with efficiency and ownership.
- You quickly learn new technologies, tackle complex problems, and have a passion for science.
- You are self-motivated and proactive, prioritize effectively, and drive work forward with minimal supervision.
Qualifications
- BS (10+ years), MS (7+ years), or PhD (0–3+ years) in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a closely related field.
- Extensive experience with advanced mass spectrometers (Orbitrap, Q-TOF, Triple Quadrupole, etc.), liquid chromatography, and data processing software (Proteome Discoverer, Skyline, Protein Metrics, etc.) (desired).
- Knowledge/experience with extended monoclonal antibody characterization by mass spectrometry to support cell line and upstream/downstream development (plus).
- Experience with automated liquid-handling systems (e.g., Bravo, KingFisher) and with experimental design/data analysis (e.g., DOE, molecular modeling, graphing, statistical tools such as JMP) (plus).
Benefits
- U.S. benefits may include medical, dental, vision, life and disability insurance, fitness centers, 401(k) match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves.
- Salary range (annually): $109,900.00 - $179,300.00.
Application Instructions
- Apply now.