Sr. Scientist
Legend Biotech
August 21, 2026
On-site
Philadelphia, PA
Clinical Research and Development
Role Overview:
Sr. Scientist (Philadelphia, Pennsylvania). Initiative-taking scientist to advance next-generation in-vivo CAR cell therapies for cancer and autoimmune indications.
Key Responsibilities:
- Lead, design, and optimize research exploring next generation in-vivo CAR-T.
- Use published literature to generate novel solutions for in-vivo cell therapy challenges.
- Isolate immune cells from leukopak/blood of donors or patients and evaluate in-vivo CAR virus using in-vitro assays and in-vivo mouse models.
- Conduct solid-tumor research using cell biology methods (cell culture, transfection, FACS, cell-based functional assays).
- Package/titer engineered viruses; characterize particles (protein/PCR assays); measure transduction rate (flow and VCN).
- Generate/manage/maintain critical data (including ELN) and deliver results via presentations.
- Maintain compliance with GLP and EHS protocols.
Requirements:
- PhD in Immunology or related discipline.
- 4+ years cell & gene therapy experience (in-vivo CAR-T preferred).
- Advanced immune cell analytics/assay development (multi-parameter flow; cytotoxicity; cytokine release ELISA/MSD multiplex).
- Lentivirus characterization/quantification (VCN and flow).
- Solid tumor models and in-vivo cell-specific gene delivery is a plus.
- Publications or patents; independent project execution.
- Strong knowledge of immunology/immunotherapy; solid tumor model knowledge preferred.
- Proficiency with gene delivery (LVV/VLP/LNP), lentivirus production/titering/transduction, and molecular/cellular vector evaluation.
Benefits (explicitly stated):
- Medical/dental/vision; 401(k) match; 8 weeks paid parental leave; paid time off; base pay range $127,313–$167,099; performance bonus and/or equity (eligible roles).
Sr. Scientist (Philadelphia, Pennsylvania). Initiative-taking scientist to advance next-generation in-vivo CAR cell therapies for cancer and autoimmune indications.
Key Responsibilities:
- Lead, design, and optimize research exploring next generation in-vivo CAR-T.
- Use published literature to generate novel solutions for in-vivo cell therapy challenges.
- Isolate immune cells from leukopak/blood of donors or patients and evaluate in-vivo CAR virus using in-vitro assays and in-vivo mouse models.
- Conduct solid-tumor research using cell biology methods (cell culture, transfection, FACS, cell-based functional assays).
- Package/titer engineered viruses; characterize particles (protein/PCR assays); measure transduction rate (flow and VCN).
- Generate/manage/maintain critical data (including ELN) and deliver results via presentations.
- Maintain compliance with GLP and EHS protocols.
Requirements:
- PhD in Immunology or related discipline.
- 4+ years cell & gene therapy experience (in-vivo CAR-T preferred).
- Advanced immune cell analytics/assay development (multi-parameter flow; cytotoxicity; cytokine release ELISA/MSD multiplex).
- Lentivirus characterization/quantification (VCN and flow).
- Solid tumor models and in-vivo cell-specific gene delivery is a plus.
- Publications or patents; independent project execution.
- Strong knowledge of immunology/immunotherapy; solid tumor model knowledge preferred.
- Proficiency with gene delivery (LVV/VLP/LNP), lentivirus production/titering/transduction, and molecular/cellular vector evaluation.
Benefits (explicitly stated):
- Medical/dental/vision; 401(k) match; 8 weeks paid parental leave; paid time off; base pay range $127,313–$167,099; performance bonus and/or equity (eligible roles).