Sr. Research Associate, Protein Design

Role: Senior Research Associate supporting protein expression, purification, and biophysical characterization for Moderna's Infectious Disease Vaccine and Therapeutics programs. Responsibilities: execute and optimize recombinant protein workflows in mammalian and bacterial (E. coli) systems; perform protein purification via chromatography; characterize proteins using techniques like SDS-PAGE, SEC-MALS, DSC, DSF, BLI, and flow cytometry; support development of challenging proteins and complex antigens; analyze data, troubleshoot workflows, and develop AI-assisted high-throughput screening methods; collaborate with multidisciplinary teams and maintain accurate records. Requirements: Bachelor's degree in Biochemistry, Molecular Biology, or related field with 2+ years of relevant experience in recombinant protein expression; hands-on experience with mammalian and bacterial expression systems; proficiency in protein purification and characterization techniques. Preferred: 4+ years of experience or Master's with 2+ years; expertise with FPLC, troubleshooting, and advanced biophysical methods; strong data analysis skills and team collaboration. HighValue: focus on vaccine and therapeutic protein development, leveraging AI for high-throughput analysis, onsite role in Cambridge, MA, with a clear emphasis on intersecting biochemistry and biophysical characterization techniques in a fast-paced research environment.