Sr. Principal Statistician, Biostatistics
Jazz Pharmaceuticals
August 13, 2026
On-site
Philadelphia, PA
Clinical Research and Development
If you are a current Jazz employee please apply via the Internal Career site.
The Sr. Principal Statistician, Biostatistics will lead statistical work supporting Phase I–IV clinical studies and regulatory filings.
Responsibilities:
- Lead/participate in meetings to optimize study designs, endpoints, and analysis strategies.
- Collaborate with study teams to meet study and reporting timelines.
- Support study protocol development and implementation.
- Review/input study data capture systems and participate in validation.
- Develop statistical programs to simulate trial operating characteristics; perform analyses; prepare data displays; verify accuracy/validity of programmed analyses.
- Write statistical analysis plans; analyze/validate data; interpret results.
- Support project lead statistician and oversee external vendor work.
- Prepare for and respond to regulatory agency questions; attend agency meetings.
- Monitor CRO standards; review/validate CRO deliverables.
- Collaborate with medical writers on clinical reports and summaries.
Required/Preferred Qualifications & Skills:
- MS/MPH (stats/math/related with statistical focus) with >4 years pharma/biotech experience OR PhD with statistical focus.
- Clinical trial design and analysis expertise (complex methods/models; inference; hypothesis testing; estimation; parametric/non-parametric models; sample size principles; experiment design; Phase II–IV analysis).
- SAS and R experience (other languages a plus).
- Regulatory knowledge (e.g., ICH).
- Excellent communication/writing; attention to detail; strong time management; can work with minimal supervision.
- Preferred: Bayesian and adaptive design knowledge.
- Proficient SAS & R; understanding of CDISC SDTM/ADaM standards.
Benefits (as stated): medical/dental/vision insurance, 401k, flexible paid vacation; possible discretionary bonus/incentives and discretionary equity.
Base pay range (as stated): $156,000–$234,000.
The Sr. Principal Statistician, Biostatistics will lead statistical work supporting Phase I–IV clinical studies and regulatory filings.
Responsibilities:
- Lead/participate in meetings to optimize study designs, endpoints, and analysis strategies.
- Collaborate with study teams to meet study and reporting timelines.
- Support study protocol development and implementation.
- Review/input study data capture systems and participate in validation.
- Develop statistical programs to simulate trial operating characteristics; perform analyses; prepare data displays; verify accuracy/validity of programmed analyses.
- Write statistical analysis plans; analyze/validate data; interpret results.
- Support project lead statistician and oversee external vendor work.
- Prepare for and respond to regulatory agency questions; attend agency meetings.
- Monitor CRO standards; review/validate CRO deliverables.
- Collaborate with medical writers on clinical reports and summaries.
Required/Preferred Qualifications & Skills:
- MS/MPH (stats/math/related with statistical focus) with >4 years pharma/biotech experience OR PhD with statistical focus.
- Clinical trial design and analysis expertise (complex methods/models; inference; hypothesis testing; estimation; parametric/non-parametric models; sample size principles; experiment design; Phase II–IV analysis).
- SAS and R experience (other languages a plus).
- Regulatory knowledge (e.g., ICH).
- Excellent communication/writing; attention to detail; strong time management; can work with minimal supervision.
- Preferred: Bayesian and adaptive design knowledge.
- Proficient SAS & R; understanding of CDISC SDTM/ADaM standards.
Benefits (as stated): medical/dental/vision insurance, 401k, flexible paid vacation; possible discretionary bonus/incentives and discretionary equity.
Base pay range (as stated): $156,000–$234,000.