Sr Principal Statistician
Jazz Pharmaceuticals
August 19, 2026
Remote friendly (Palo Alto, CA)
United States
Clinical Research and Development
Application instruction:
- If you are a current Jazz employee please apply via the Internal Career site.
Brief description:
- Senior Principal Statistician, Biostatistics: Lead statistician on individual and integrated studies; design and report Phase I–IV clinical studies and regulatory filings (under supervision). Own statistical aspects of study design, analysis/validation, and documentation; develop and execute statistical strategy, design, and analyses for clinical trials; manage external vendor statistical/programming work.
Essential functions:
- Optimize study designs, endpoints, and analysis strategies in protocols.
- Support protocol development and study timelines.
- Review and validate data capture systems.
- Develop statistical programs (simulation, analysis, data displays); verify statistical programming outputs.
- Write/review statistical analysis plans; oversee analysis and validation; interpret results.
- Prepare for and attend regulatory agency meetings; respond to statistical questions.
- Review/validate CRO deliverables; act as statistical SME for clinical reports and integrated summaries.
Required knowledge/skills:
- Clinical trial design/analysis with complex methods/models; hypothesis testing/estimation; parametric/non-parametric models; sample size principles; Phase II–IV data analysis.
- SAS and R experience.
- Knowledge of regulatory requirements (e.g., ICH), CDISC standards, statistical contributions to filings.
- Strong communication, attention to detail, time management; can work without close supervision.
Education/experience:
- MS/MPH in statistics/mathematics/related (statistical focus) + >4 years pharma/biotech, or PhD + >2 years.
- Drug development regulatory knowledge.
Preferred:
- Oncology/hematology area; Bayesian and adaptive design experience; proficient SAS & R; leadership/writing/communication.
Benefits (explicitly stated):
- Medical/dental/vision, 401(k), flexible paid vacation.
- If you are a current Jazz employee please apply via the Internal Career site.
Brief description:
- Senior Principal Statistician, Biostatistics: Lead statistician on individual and integrated studies; design and report Phase I–IV clinical studies and regulatory filings (under supervision). Own statistical aspects of study design, analysis/validation, and documentation; develop and execute statistical strategy, design, and analyses for clinical trials; manage external vendor statistical/programming work.
Essential functions:
- Optimize study designs, endpoints, and analysis strategies in protocols.
- Support protocol development and study timelines.
- Review and validate data capture systems.
- Develop statistical programs (simulation, analysis, data displays); verify statistical programming outputs.
- Write/review statistical analysis plans; oversee analysis and validation; interpret results.
- Prepare for and attend regulatory agency meetings; respond to statistical questions.
- Review/validate CRO deliverables; act as statistical SME for clinical reports and integrated summaries.
Required knowledge/skills:
- Clinical trial design/analysis with complex methods/models; hypothesis testing/estimation; parametric/non-parametric models; sample size principles; Phase II–IV data analysis.
- SAS and R experience.
- Knowledge of regulatory requirements (e.g., ICH), CDISC standards, statistical contributions to filings.
- Strong communication, attention to detail, time management; can work without close supervision.
Education/experience:
- MS/MPH in statistics/mathematics/related (statistical focus) + >4 years pharma/biotech, or PhD + >2 years.
- Drug development regulatory knowledge.
Preferred:
- Oncology/hematology area; Bayesian and adaptive design experience; proficient SAS & R; leadership/writing/communication.
Benefits (explicitly stated):
- Medical/dental/vision, 401(k), flexible paid vacation.