Sr Principal Scientist - Imaging

Role Summary

The Senior Principal Scientist is responsible for spearheading the imaging biomarker strategy and implementation across cardiovascular and metabolic indications in early- and late-phase clinical trials. This role involves collaboration with cross-functional study teams where you will lead the design of complex imaging approaches to test the efficacy and safety of Regeneron products. In this role, you will be responsible for developing and validating novel imaging-based biomarkers to address the needs of the Regeneron experimental therapies.

Responsibilities

• Collaborate closely with Research and Global Development colleagues to formulate appropriate imaging biomarker strategies to inform and advance the Regeneron clinical pipeline.
• Provide leadership during the strategy phase of study design, guiding the team on all imaging aspects of the study, presenting the imaging components of the integrated biomarker strategy to senior management for endorsement, and authoring of key study documents.
• Work closely with Clinical Imaging Operations and Clinical Trial Management to ensure the delivery of high-quality imaging data in clinical studies. This includes drafting imaging manuals and other documents for the trial, supporting the clinical team during the study start-up phase, and monitoring data integrity throughout the trial.
• Supervise imaging Clinical Research Organizations (CROs) to ensure execution of imaging components in the trial, timely address any image quality issues, and ensure flawless delivery of key study imaging data and achievements
• Identify gaps in imaging assessments for particular indications and propose novel biomarkers, and spearhead validation through collaboration with other functions within Regeneron or external institutions.
• Support regulatory submission packages as the imaging subject matter expert

Qualifications

• Required: PhD or MD/PhD with a minimum of 6 years of experience in clinical imaging, specifically within cardiovascular and/or metabolic domains.
• Required: Extensive expertise in the acquisition and analysis of imaging modalities including MRI, CT, ultrasound, and echocardiography.
• Preferred: Experience in industry-sponsored clinical trials.

Skills

• Work efficiently in a fast-paced, collaborative environment
• Communicate effectively across clinical teams and functions, and with senior management
• Broad knowledge of imaging and understanding of image standardization challenges across sites and countries
• Strong analytical and problem-solving skills
• Ability to address complex problems with innovative methods

Education

• PhD or MD/PhD required

Additional Requirements

• Regulatory submission support as imaging subject matter expert