Sr. Principal Scientist, Clinical Pharmacology
Neurocrine Biosciences
August 13, 2026
Remote friendly (San Diego, CA)
United States
Clinical Research and Development
About The Role
Provides Clinical Pharmacology scientific support for one or more clinical development programs. Leads planning, execution, interpretation, and communication of Clinical Pharmacology activities and contributes to dose selection and study design across diverse therapeutic modalities. Represents Clinical Pharmacology on cross-functional teams to enable development and regulatory decision-making.
Your Contributions (include, but are not limited to)
- Develop and execute Clinical Pharmacology strategies for assigned programs/areas.
- Lead PK/PD/exposure-response planning, conduct, interpretation, and reporting.
- Provide scientific input for protocol design, dose selection, and study interpretation.
- Oversee deliverables: analysis plans/reports and contributions to regulatory documents (INDs, CTAs, NDAs, briefing books, Investigator Brochures).
- Use modeling/simulation to inform study design, dose justification, and decisions.
- Manage/oversee vendors and CROs for timely, high-quality analyses.
- Ensure activities comply with SOPs, regulatory guidance, and internal standards.
- Communicate results/recommendations; prepare/deliver scientific presentations.
- Identify and resolve complex scientific/operational issues; escalate risks as appropriate.
- Contribute to departmental strategies/policies; mentor junior staff.
Common Knowledge & Skills
- Strong interpersonal, communication, problem-solving, analytical thinking.
- Project management/leadership; meet multiple deadlines with accuracy/efficiency.
- Ability to influence all levels; translate strategy to tactics; lead multiple teams.
Job Specific Knowledge & Qualifications
- Extensive PK/PD data interpretation in clinical development.
- Managing clinical CROs; preparation of INDs/CTAs/NDAs/MAAs.
- Strong in silico modeling and simulation; knowledge of current regulatory guidance.
Requirements
- Bachelor’s in chemistry, life sciences, or closely related discipline, and 8+ years pharmaceutical/biotech experience, including managing clinical CROs; experience with INDs/CTAs/NDAs/MAAs and in silico modeling beneficial.
OR
- Master’s in Pharmacokinetics/Pharmaceutical Sciences or related + 6+ years.
OR
- PhD Pharmacokinetics/Pharmaceutical Sciences or related, or PharmD + 4+ years.
Benefits (if explicitly stated)
- Annual bonus (target 30% of earned base salary) and eligibility for equity long-term incentive; retirement match; paid vacation/holidays/personal days; paid caregiver/parental and medical leave; medical/dental/vision.
Salary (if explicitly stated)
- Annual base salary range: $156,900.00–$214,000.00.
Provides Clinical Pharmacology scientific support for one or more clinical development programs. Leads planning, execution, interpretation, and communication of Clinical Pharmacology activities and contributes to dose selection and study design across diverse therapeutic modalities. Represents Clinical Pharmacology on cross-functional teams to enable development and regulatory decision-making.
Your Contributions (include, but are not limited to)
- Develop and execute Clinical Pharmacology strategies for assigned programs/areas.
- Lead PK/PD/exposure-response planning, conduct, interpretation, and reporting.
- Provide scientific input for protocol design, dose selection, and study interpretation.
- Oversee deliverables: analysis plans/reports and contributions to regulatory documents (INDs, CTAs, NDAs, briefing books, Investigator Brochures).
- Use modeling/simulation to inform study design, dose justification, and decisions.
- Manage/oversee vendors and CROs for timely, high-quality analyses.
- Ensure activities comply with SOPs, regulatory guidance, and internal standards.
- Communicate results/recommendations; prepare/deliver scientific presentations.
- Identify and resolve complex scientific/operational issues; escalate risks as appropriate.
- Contribute to departmental strategies/policies; mentor junior staff.
Common Knowledge & Skills
- Strong interpersonal, communication, problem-solving, analytical thinking.
- Project management/leadership; meet multiple deadlines with accuracy/efficiency.
- Ability to influence all levels; translate strategy to tactics; lead multiple teams.
Job Specific Knowledge & Qualifications
- Extensive PK/PD data interpretation in clinical development.
- Managing clinical CROs; preparation of INDs/CTAs/NDAs/MAAs.
- Strong in silico modeling and simulation; knowledge of current regulatory guidance.
Requirements
- Bachelor’s in chemistry, life sciences, or closely related discipline, and 8+ years pharmaceutical/biotech experience, including managing clinical CROs; experience with INDs/CTAs/NDAs/MAAs and in silico modeling beneficial.
OR
- Master’s in Pharmacokinetics/Pharmaceutical Sciences or related + 6+ years.
OR
- PhD Pharmacokinetics/Pharmaceutical Sciences or related, or PharmD + 4+ years.
Benefits (if explicitly stated)
- Annual bonus (target 30% of earned base salary) and eligibility for equity long-term incentive; retirement match; paid vacation/holidays/personal days; paid caregiver/parental and medical leave; medical/dental/vision.
Salary (if explicitly stated)
- Annual base salary range: $156,900.00–$214,000.00.