Sr Principal Scientist / Associate Director, Biomarker Assay Development Laboratory

Role: Senior Principal Scientist / Associate Director leading the Biomarker Assay Development Laboratory, focusing on translational research to support drug discovery and clinical development across renal, liver, fibrosis, and emerging diseases. Responsibilities include designing and qualifying biomarker assays for target engagement, pharmacodynamics, and patient stratification; managing laboratory operations, resource planning, and external collaborations; and providing scientific leadership to inform translational strategies. The role involves building and mentoring a high-performing team of biomarker scientists and partnering with cross-functional teams such as Translational Medicine and Data Science. Requirements include a Ph.D., MD, or equivalent in life sciences, extensive experience in developing cellular, circulating, proteomic, genetic, and genomic biomarker assays within pharma/biotech contexts, with expertise in platforms like PCR, NGS, immunoassays, and mass spectrometry. Strong leadership, collaboration, and stakeholder engagement skills are essential. Preferred qualifications include experience in multiomics profiling and patient stratification. The work is based in Cambridge, MA, with relocation support, and involves strategic scientific innovation within a high-impact translational research environment.