Sr. Manager Business Effectiveness PMO

Role Summary

The Sr. Manager, Business Effectiveness PMO leads high-impact commercial programs that drive organizational effectiveness, growth, and transformation. This role oversees the planning and execution of enterprise-wide initiatives including organizational restructures, commercialization readiness, and market expansion, while ensuring strong governance, risk management, and delivery discipline. Partnering closely with Commercial, HR, and Finance leaders, this role integrates program and change management to ensure initiatives are successfully adopted and deliver sustained business value. The Sr. Manager also provides oversight of vendor partnerships and commercial budget management, serving as a trusted advisor during periods of significant change. This position is based in either San Diego, CA, or Princeton, NJ, with a hybrid model requiring in-office work three days per week on average.

Responsibilities

• Lead enterprise-wide commercial programs, including organizational restructures, commercialization readiness, and market expansion initiatives.
• Define program scope, objectives, governance, resourcing, and success metrics in partnership with Commercial leadership and executive sponsors.
• Develop and maintain integrated program plans, manage dependencies, track milestones, and proactively identify and mitigate risks.
• Ensure consistent application of PMO standards, governance, reporting, and best practices across all initiatives.
• Drive portfolio-level prioritization and execution to support differentiated commercial growth.

Qualifications

• Required: Bachelor's degree in a related field; equivalent experience may be considered.
• Required: 3–5 years of progressive experience in a commercial role, with cross-functional leadership.
• Preferred: Project or program management certifications (e.g., PMP, Six Sigma).
• Preferred: Change management certification or demonstrated hands-on experience applying change management principles.
• Preferred: Experience in the pharmaceutical, biotech, medical device, or healthcare industry.
• Required: Proven experience leading complex, enterprise-wide programs supporting commercial growth and organizational change.
• Required: Experience partnering with senior leaders and executive sponsors to drive alignment and results.
• Required: Strong program and project management expertise with knowledge of PMO governance, methodologies, and best practices.
• Required: Demonstrated change management expertise, including adoption, resistance management, and value realization.
• Required: High commercial acumen with understanding of pharmaceutical commercialization lifecycle.
• Required: Exceptional leadership and influence skills with the ability to drive outcomes without direct authority.
• Required: Outstanding written and verbal communication skills for executive audiences.
• Required: Highly analytical and structured problem-solving approach with risk management and decision-making capabilities.

Education

• Bachelor's degree in a related field (or equivalent experience)

Additional Requirements

• Travel independently overnight and/or work after hours as required by travel schedule or business needs.
• Physical requirements: regular standing, walking, sitting, use of hands, and ability to lift up to 20 pounds as needed.